| Tag | Content |
|---|
| CPLM ID | CPLM-002662 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrin alpha-IIb |
Protein Synonyms/Alias | GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41; Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2 |
Gene Name | ITGA2B |
Gene Synonyms/Alias | GP2B; ITGAB |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 765 | NSQNPNSKIVLLDVP | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
Sequence Annotation | REPEAT 35 96 FG-GAP 1.
REPEAT 110 173 FG-GAP 2.
REPEAT 186 238 FG-GAP 3.
REPEAT 251 310 FG-GAP 4.
REPEAT 311 371 FG-GAP 5.
REPEAT 373 432 FG-GAP 6.
REPEAT 434 496 FG-GAP 7.
MOTIF 1022 1026 GFFKR motif.
MOD_RES 891 891 Pyrrolidone carboxylic acid; in light
CARBOHYD 46 46 N-linked (GlcNAc...).
CARBOHYD 280 280 N-linked (GlcNAc...).
CARBOHYD 601 601 N-linked (GlcNAc...).
CARBOHYD 711 711 N-linked (GlcNAc...).
CARBOHYD 874 874 O-linked (GalNAc...); in alloantigen HPA-
CARBOHYD 878 878 O-linked (GalNAc...).
CARBOHYD 962 962 N-linked (GlcNAc...).
DISULFID 87 96
DISULFID 138 161
DISULFID 177 198
DISULFID 504 515
DISULFID 521 576
DISULFID 633 639
DISULFID 705 718
DISULFID 857 911 Interchain (between heavy and light
DISULFID 916 921 |
Keyword | 3D-structure; Alternative splicing; Calcium; Cell adhesion; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Integrin; Membrane; Metal-binding; Polymorphism; Pyrrolidone carboxylic acid; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1039 AA |
Protein Sequence | MARALCPLQA LWLLEWVLLL LGPCAAPPAW ALNLDPVQLT FYAGPNGSQF GFSLDFHKDS 60
HGRVAIVVGA PRTLGPSQEE TGGVFLCPWR AEGGQCPSLL FDLRDETRNV GSQTLQTFKA 120
RQGLGASVVS WSDVIVACAP WQHWNVLEKT EEAEKTPVGS CFLAQPESGR RAEYSPCRGN 180
TLSRIYVEND FSWDKRYCEA GFSSVVTQAG ELVLGAPGGY YFLGLLAQAP VADIFSSYRP 240
GILLWHVSSQ SLSFDSSNPE YFDGYWGYSV AVGEFDGDLN TTEYVVGAPT WSWTLGAVEI 300
LDSYYQRLHR LRGEQMASYF GHSVAVTDVN GDGRHDLLVG APLYMESRAD RKLAEVGRVY 360
LFLQPRGPHA LGAPSLLLTG TQLYGRFGSA IAPLGDLDRD GYNDIAVAAP YGGPSGRGQV 420
LVFLGQSEGL RSRPSQVLDS PFPTGSAFGF SLRGAVDIDD NGYPDLIVGA YGANQVAVYR 480
AQPVVKASVQ LLVQDSLNPA VKSCVLPQTK TPVSCFNIQM CVGATGHNIP QKLSLNAELQ 540
LDRQKPRQGR RVLLLGSQQA GTTLNLDLGG KHSPICHTTM AFLRDEADFR DKLSPIVLSL 600
NVSLPPTEAG MAPAVVLHGD THVQEQTRIV LDCGEDDVCV PQLQLTASVT GSPLLVGADN 660
VLELQMDAAN EGEGAYEAEL AVHLPQGAHY MRALSNVEGF ERLICNQKKE NETRVVLCEL 720
GNPMKKNAQI GIAMLVSVGN LEEAGESVSF QLQIRSKNSQ NPNSKIVLLD VPVRAEAQVE 780
LRGNSFPASL VVAAEEGERE QNSLDSWGPK VEHTYELHNN GPGTVNGLHL SIHLPGQSQP 840
SDLLYILDIQ PQGGLQCFPQ PPVNPLKVDW GLPIPSPSPI HPAHHKRDRR QIFLPEPEQP 900
SRLQDPVLVS CDSAPCTVVQ CDLQEMARGQ RAMVTVLAFL WLPSLYQRPL DQFVLQSHAW 960
FNVSSLPYAV PPLSLPRGEA QVWTQLLRAL EERAIPIWWV LVGVLGGLLL LTILVLAMWK 1020
VGFFKRNRPP LEEDDEEGE 1039 |
Gene Ontology | GO:0009897; C:external side of plasma membrane; IEA:Compara. GO:0005925; C:focal adhesion; IEA:Compara. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0008305; C:integrin complex; IEA:InterPro. GO:0031092; C:platelet alpha granule membrane; TAS:Reactome. GO:0050840; F:extracellular matrix binding; IEA:Compara. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0007411; P:axon guidance; TAS:Reactome. GO:0007155; P:cell adhesion; TAS:ProtInc. GO:0007160; P:cell-matrix adhesion; IEA:Compara. GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW. GO:0030168; P:platelet activation; TAS:Reactome. GO:0002576; P:platelet degranulation; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |