UniProt Accession

 MSRB2_MOUSE; Q78J03 

Genbank Protein ID

 AL928806; BC021619 

Genbank Nucleotide ID

 CAM21786.1; AAH21619.1 

Protein Name

 Methionine-R-sulfoxide reductase B2, mitochondrial 

Protein Synonyms/Alias

 MsrB2 

Gene Name

 Msrb2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
37	KDTGSLTKSKRSLSE	acetylation	[1]
37	KDTGSLTKSKRSLSE	succinylation	[1]
76	SGMYLNNKETGMYHC	acetylation	[2, 3]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance (By similarity). 

Sequence Annotation

 ACT_SITE 162 162 Nucleophile (By similarity).
 METAL 83 83 Zinc (By similarity).
 METAL 86 86 Zinc (By similarity).
 METAL 139 139 Zinc (By similarity).
 METAL 142 142 Zinc (By similarity).  

Keyword

 3D-structure; Complete proteome; Metal-binding; Mitochondrion; Oxidoreductase; Reference proteome; Transit peptide; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HGNC.
 GO:0033743; F:peptide-methionine (R)-S-oxide reductase activity; IDA:HGNC.
 GO:0008270; F:zinc ion binding; IDA:HGNC.
 GO:0030091; P:protein repair; IDA:HGNC. 

Interpro

 IPR002579; Met_Sox_Rdtase_MsrB.
 IPR011057; Mss4-like. 

Pfam

 PF01641; SelR 

SMART

  

PROSITE

  

PRINTS