UniProt Accession

 SCMC1_HUMAN; Q6NUK1; B7ZAI9; Q5T331; Q5T485; Q6PJJ9; Q705K4; Q9P129 

Genbank Protein ID

 AJ619987; AJ619961; AK292567; AK316304; AL390036; AL359258; AL390036; AL359258; AL359258; AL390036; AL359258; AL390036; CH471156; CH471156; BC014519; BC068561; AF123303 

Genbank Nucleotide ID

 CAF04493.1; CAF04058.1; BAF85256.1; BAH14675.1; CAI13622.1; CAI13622.1; CAI13623.1; CAI13623.1; CAI14512.1; CAI14512.1; CAI14513.1; CAI14513.1; EAW51254.1; EAW51255.1; AAH14519.1; AAH68561.1; AAF28888.1 

Protein Name

 Calcium-binding mitochondrial carrier protein SCaMC-1 

Protein Synonyms/Alias

 Mitochondrial ATP-Mg/Pi carrier protein 1; Mitochondrial Ca(2+)-dependent solute carrier protein 1; Small calcium-binding mitochondrial carrier protein 1; Solute carrier family 25 member 24 

Gene Name

 SLC25A24 

Gene Synonyms/Alias

 APC1; MCSC1; SCAMC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	LGQDAEEKIFTTGDV	ubiquitination	[1, 2]
243	GGFRQMVKEGGIRSL	acetylation	[3]
336	DCAKKILKHEGLGAF	acetylation	[3, 4, 5]
437	LFRRIISKEGIPGLY	acetylation	[3, 4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

 Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. 

Sequence Annotation

 DOMAIN 19 54 EF-hand 1.
 DOMAIN 55 88 EF-hand 2.
 DOMAIN 86 121 EF-hand 3.
 DOMAIN 122 157 EF-hand 4.
 REPEAT 192 278 Solcar 1.
 REPEAT 286 371 Solcar 2.
 REPEAT 383 471 Solcar 3.
 MOD_RES 336 336 N6-acetyllysine.
 MOD_RES 437 437 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Calcium; Complete proteome; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 477 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR002167; Graves_DC.
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 

Pfam

 PF13499; EF_hand_5
 PF00153; Mito_carr 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50920; SOLCAR 

PRINTS

 PR00928; GRAVESDC.
 PR00926; MITOCARRIER.