| Tag | Content |
|---|
| CPLM ID | CPLM-011103 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Silent chromatin protein ESC1 |
Protein Synonyms/Alias | Establishes silent chromatin protein 1 |
Gene Name | ESC1 |
Gene Synonyms/Alias | YMR219W; YM8261.13; YM9959.01 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 338 | TKIPVIEKYESDEHK | acetylation | [1] | | 451 | SRDQGFAKDAYTKNK | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Involved in the clustering of telomeres at the nuclear periphery, forming discrete subcompartments that accumulate a complex of histone-binding silencing factors like SIR4. Required for SIR4-mediated anchoring and partitioning of plasmids. |
Sequence Annotation | MOD_RES 500 500 Phosphothreonine.
MOD_RES 532 532 Phosphoserine.
MOD_RES 579 579 Phosphoserine.
MOD_RES 583 583 Phosphoserine.
MOD_RES 608 608 Phosphoserine.
MOD_RES 662 662 Phosphoserine.
MOD_RES 865 865 Phosphoserine.
MOD_RES 866 866 Phosphoserine.
MOD_RES 888 888 Phosphoserine.
MOD_RES 911 911 Phosphoserine.
MOD_RES 937 937 Phosphoserine.
MOD_RES 1092 1092 Phosphoserine.
MOD_RES 1096 1096 Phosphoserine.
MOD_RES 1098 1098 Phosphoserine.
MOD_RES 1166 1166 Phosphoserine.
MOD_RES 1176 1176 Phosphoserine.
MOD_RES 1178 1178 Phosphoserine.
MOD_RES 1214 1214 Phosphoserine.
MOD_RES 1254 1254 Phosphoserine.
MOD_RES 1290 1290 Phosphoserine.
MOD_RES 1326 1326 Phosphoserine.
MOD_RES 1332 1332 Phosphoserine.
MOD_RES 1403 1403 Phosphoserine.
MOD_RES 1409 1409 Phosphoserine.
MOD_RES 1450 1450 Phosphoserine.
MOD_RES 1454 1454 Phosphoserine.
MOD_RES 1539 1539 Phosphoserine.
MOD_RES 1590 1590 Phosphoserine.
MOD_RES 1591 1591 Phosphoserine. |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1658 AA |
Protein Sequence | MSKKKETFTP RANKLKLTTP RRKLKILSSL LDADEDSKMK DQHGYSRVHN DKYRVAKPTQ 60
HSTLHESISS RRSSHIHNKS LHEDSARALS WVDSLINRGK SILTTLEKED ALFERSLEEE 120
RQRFQLHDSL MNKYTGNSKS HQRLIDLRKS QYGTDTSFQN NDEIPLDSFI SSPLPDAEDE 180
SSSNIDSDKD EDLEGKQSLI KDFDLENDEY ELSEEEKNSD GQSSPSIMIL SDEEYAEEGA 240
LQDVSNDEYA EEEGQVERKN IGQEQANVEN ATQISSSDSS EGQNYSEGVE MELEDDIDVE 300
SDAEKDESQG AEGTEHSVDF SKYMQPRTDN TKIPVIEKYE SDEHKVHQRY SEDGAFDFGS 360
VNISVDDESE DEESQAESYS ANAENVYHHN EHELDDKELI EDIESSDSES QSAQESEQGS 420
EDDFEYKMKN EKSTSEETEN TSESRDQGFA KDAYTKNKVE QQENDEEPEK DDIIRSSLDK 480
NFHGNNNKSE YSENVLENET DPAIVERENQ INDVEGYDVT GKSVESDLHE HSPDNLYDLA 540
ARAMLQFQQS RNSNCPQKEE QVSESYLGHS NGSNLSGRSL DESEEQIPLK DFTGENNNNL 600
KTDRGDLSSS VEIEVEKVSE KKLDGSTEKE LVPLSTDTTI NNSSLGNEDS IYYSLDDADA 660
ISENLTDVPL MEIKTTPKYE VVISESVYSS TSYEDNTVAM PPQVEYTSPF MNDPFNSLND 720
DYEKKHDLLK STLAALAPAF TKKDAEFVEA GVTKSCLTST SGHTNIFHTS KETKQVSDLD 780
ESTENVTFEN ENTGDENKNQ SKNFPGVANS TDKSTEDNTD EKYFSAINYT NVTGDSSCED 840
IIETASNVEE NLRYCEKDMN EAEMSSGDEC VKQNDDGSKT QISFSTDSPD NFQESNDNTE 900
FSSTKYKVRN SDLEDDESLK KELTKAEVVD KLDEEESEDS YEQDYADPEP GNDEGSNENI 960
VKGTKKDTLG IVEPENEKVN KVHEEETLFE ANVSSSVNVQ NKDMHTDVIN QEAQANYEAG 1020
ERKYYIQNTD TEEAHISIIE RIDENAIGNN MEIPERSCVE KTHNEVLFER RATTIENTKA 1080
LENNTNMHDQ VSQACSDSDR DQDSTAEKNV EGSAKHNLDI RVSSSEIESV EPLKPESDRS 1140
NIFSSPIRVI GAVVKGVGKV VDVAESFVKK IDVMDSESDD NVDIGDYNQD IFNKSNSTDA 1200
SVNMKSVSSK ERDSDEDEAV ILGGVTAEAH NDNGNNSRVI NIDPTTNGAY EEDSEVFRQQ 1260
VKDKENLHKS EEPLVEGLQS EQHFEKKDHS ENEEEFDTIY GDITSANIHS NAPDDIKRQQ 1320
LLKNLSDLEN YSQRLIEDSR RGKNQEESDE VNTSRERDLT FEKSVNEKYA GAIEEDTFSE 1380
LDISIQHPEH EEDLDLSNNQ ERSIEELNSE PEEAELYELE IEGPTETAAS SKMNDDERQR 1440
GNIPSTDLPS DPPSDKEEVT DSYPYSNSEN ITAEKSAPTS PEVYEIFSDT PNEVPMEIND 1500
EIPATTLEKH DKTNVTSVLD DRSEHLSSHD VDNEPHDNSI NIKVNEGEEP EHQAVDIPVK 1560
VEVKEEQEEM PSKSVLEEQK PSMELINDKS SPENNNDEET NREKDKTKAK KKSRKRNYNS 1620
RRRKRKITEG SSAASNTKRR RGHEPKSRGQ NTHPSVDK 1658 |
Gene Ontology | GO:0034399; C:nuclear periphery; IDA:SGD. GO:0006348; P:chromatin silencing at telomere; IMP:SGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |