CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016527
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box only protein 38 
Protein Synonyms/Alias
 Modulator of KLF7 activity; MoKA 
Gene Name
 Fbxo38 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
909KRKRTADKSTSTSDPacetylation[1]
986FDYAQCKKLNMDQVLubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination. 
Sequence Annotation
 DOMAIN 30 75 F-box.
 REGION 59 119 Interaction with KLF7.
 MOD_RES 742 742 Phosphoserine (By similarity).
 MOD_RES 832 832 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1194 AA 
Protein Sequence
MGPRKKSAKV CVMDSEVAEE MTADEEKDYM NQLSHEVLCH IFRYLPLQDI MCMECLSRKL 60
KEAVTLYLRV VRVVDLCAGR WWEYMPSGFT DSSFLTLLKK MPDVEQLYGL HPRYLERRRV 120
RGQEAFSIPG VLEALQACPN LVGVETSHLE LVESIWTYMP HVHILGKFRN RNGAFPIPPE 180
NKLKIPIGAK IQTLHLVGVN VPEIPCIPML RHLYMKWVRL TKPQPFKDFL CISLRTFVMR 240
NCAGPTNSLK YVPLVTGLAS ARNLEHLEMV RVPFLGGLIQ HVVEDSWRSG GFRNLHTIVL 300
GACKNALEVD LGYLIITAAR RLHEVRIQPS LTKDGVFSAL KMAELEFPQF ETLHLGYVDE 360
FLLQSRMANA DLVKYGLADV VENPGIITDI GMKAVNEVFS CIKYLAIYNC PHLHNPYNWI 420
SDHSRWMRLV DINLVRCHAL KLDSFGQFVE LLPSLEFISL DQMFREPPKG CARVGLSAGT 480
GIGVSSALVS NQNSNNDNDN NAPNNNANLH DNNHHHPDDS DDDNDFRPDL QAGEAQFAAD 540
ALNEMEDMVQ EDGELVAESG NGMPAHNREV LPVDADEEQA GPSGLQRVVK PTPIADHDSE 600
SDDEEDSLEL QEVWAPKNGT RRYSEREEKT GDSGQSRETA VSGKGKTPLR KRCNNSHQTG 660
QAKPFPLEES SCEKGCQVTS EQIKADMKAA RDVSEKKKSK DVYPSCSSSS SSTAASTAGN 720
ASSPSTASQS PDFARTVTSS GSSEPSPPEV DVSRQCVCSP GGSEDSEAME EGDAESSVCP 780
RCCCLRPQES QRRTGRCSDE ERPSTSRACV VNGADGTRSA FSFRTLPQGG SSGPAHDERT 840
NGSGCGATGE DRRGSSQPES CDVQSNEDYP RRPLTRARSR LSHVPLISES EVAKTKPCHA 900
MKRKRTADKS TSTSDPVIED DHVQVLVLKS KNLVGVTMTN CGITDLVLKD CPKMMFIHAT 960
RCRVLKHLKV ENAPIVNRFD YAQCKKLNMD QVLDQILRMP PERNRIIYLR PMQQVDTLTL 1020
EQKLFSGPYP YHICIIHEFS NPPNVRNKVR IRNWMDTIAN INQELIKYEF FLEATRTEED 1080
LKKYPKYPWG REIYTLEGVV DGAPYSMISD FPWLRSLRTA EPNSFARYDF EDDEESTIYA 1140
PRRKGQLSAD ICMETIGEEI SEMRQMKRGI FQRVVAIFIH YCDVNGEPVE DDYI 1194 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR001810; F-box_dom_cyclin-like. 
Pfam
  
SMART
  
PROSITE
 PS50181; FBOX 
PRINTS