CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009828
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Casein kinase II subunit beta 
Protein Synonyms/Alias
 CK II beta; Phosvitin 
Gene Name
 Csnk2b 
Gene Synonyms/Alias
 Ck2n 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
191VPRLYGFKIHPMAYQubiquitination[1]
208LQAASNFKSPVKTIRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). Participates in Wnt signaling. 
Sequence Annotation
 REGION 188 193 Interaction with alpha subunit (By
 METAL 109 109 Zinc (By similarity).
 METAL 114 114 Zinc (By similarity).
 METAL 137 137 Zinc (By similarity).
 METAL 140 140 Zinc (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine; by autocatalysis
 MOD_RES 3 3 Phosphoserine; by autocatalysis (By
 MOD_RES 209 209 Phosphoserine (By similarity).
 MOD_RES 212 212 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Metal-binding; Phosphoprotein; Reference proteome; Wnt signaling pathway; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 215 AA 
Protein Sequence
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE 60
ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML 120
PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA 180
NQFVPRLYGF KIHPMAYQLQ LQAASNFKSP VKTIR 215 
Gene Ontology
 GO:0005956; C:protein kinase CK2 complex; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0019887; F:protein kinase regulator activity; IEA:InterPro.
 GO:0045859; P:regulation of protein kinase activity; IEA:GOC.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 
Interpro
 IPR016149; Casein_kin_II_reg-sub_a-hlx.
 IPR016150; Casein_kin_II_reg-sub_b-sht.
 IPR000704; Casein_kinase_II_reg-sub. 
Pfam
 PF01214; CK_II_beta 
SMART
 SM01085; CK_II_beta 
PROSITE
 PS01101; CK2_BETA 
PRINTS
 PR00472; CASNKINASEII.