Tag | Content |
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CPLM ID | CPLM-009950 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ancient ubiquitous protein 1 |
Protein Synonyms/Alias | |
Gene Name | Aup1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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143 | VELVESLKKFCASTR | ubiquitination | [1] | 144 | ELVESLKKFCASTRL | ubiquitination | [1] | 250 | RVQQLVAKELGQIGT | ubiquitination | [1] | 264 | TRLTPADKAEHMKRQ | ubiquitination | [1] | 269 | ADKAEHMKRQRHPRL | ubiquitination | [1] | 305 | TTLAHRVKEVLPHVP | ubiquitination | [1] | 377 | PTALTFAKSSWARQE | ubiquitination | [1] | 390 | QESLQERKQALYEYA | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (By similarity). |
Sequence Annotation | DOMAIN 296 338 CUE. MOD_RES 292 292 Phosphoserine (By similarity). MOD_RES 363 363 Phosphoserine (By similarity). MOD_RES 367 367 Phosphothreonine (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 410 AA |
Protein Sequence | MEPPPAPGPE RLFDSHRLPS DGFLLLALLL YAPVGLCLLV LRLFLGLHVF LVSCALPDSV 60 LRRFVVRTMC AVLGLVARQE DSGLRDHRVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP 120 SFVCWSRGFM EMDRRVELVE SLKKFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS 180 IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLHPIR RQLGEESEEF 240 ALRVQQLVAK ELGQIGTRLT PADKAEHMKR QRHPRLRPQS VQSSFPSPPS PSSDVQLTTL 300 AHRVKEVLPH VPLNVIQRDL ARTGCVDLTI TNLLEGAVAF MPEDVTEGSQ SPPAPSAPKF 360 PSSGLATPQP TALTFAKSSW ARQESLQERK QALYEYARRR FRERQAQEAE 410 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:Compara. GO:0016746; F:transferase activity, transferring acyl groups; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |