CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018819
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prospero homeobox protein 1 
Protein Synonyms/Alias
 Homeobox prospero-like protein PROX1; PROX-1 
Gene Name
 PROX1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
556GLSLSLIKSECGDLQsumoylation[1, 2]
Reference
 [1] Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification.
 Shan SF, Wang LF, Zhai JW, Qin Y, Ouyang HF, Kong YY, Liu J, Wang Y, Xie YH.
 FEBS Lett. 2008 Nov 12;582(27):3723-8. [PMID: 18948102]
 [2] Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells.
 Pan MR, Chang TM, Chang HC, Su JL, Wang HW, Hung WC.
 J Cell Sci. 2009 Sep 15;122(Pt 18):3358-64. [PMID: 19706680
Functional Description
 May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons (By similarity). 
Sequence Annotation
 DNA_BIND 573 635 Prospero-type homeobox.
 REGION 636 737 Prospero-like.
 MOD_RES 177 177 Phosphoserine (By similarity).
 MOD_RES 179 179 Phosphoserine (By similarity).
 MOD_RES 291 291 Phosphoserine (By similarity).
 MOD_RES 511 511 Phosphoserine (By similarity).
 MOD_RES 514 514 Phosphoserine (By similarity).
 MOD_RES 650 650 Phosphothreonine (By similarity).  
Keyword
 3D-structure; Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 737 AA 
Protein Sequence
MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS EQDVEYSVVQ 60
HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN MNKNGGTEPS FQASGLSSTG 120
SEVHQEDICS NSSRDSPPEC LSPFGRPTMS QFDMDRLCDE HLRAKRARVE NIIRGMSHSP 180
SVALRGNENE REMAPQSVSP RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK 240
QQLEDMQKQL RQLQEKFYQI YDSTDSENDE DGNLSEDSMR SEILDARAQD SVGRSDNEMC 300
ELDPGQFIDR ARALIREQEM AENKPKREGN NKERDHGPNS LQPEGKHLAE TLKQELNTAM 360
SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH NFHTANQRLQ CFGDVIIPNP 420
LDTFGNVQMA SSTDQTEALP LVVRKNSSDQ SASGPAAGGH HQPLHQSPLS ATTGFTTSTF 480
RHPFPLPLMA YPFQSPLGAP SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP 540
AHPPSTAEGL SLSLIKSECG DLQDMSEISP YSGSAMQEGL SPNHLKKAKL MFFYTRYPSS 600
NMLKTYFSDV KFNRCITSQL IKWFSNFREF YYIQMEKYAR QAINDGVTST EELSITRDCE 660
LYRALNMHYN KANDFEVPER FLEVAQITLR EFFNAIIAGK DVDPSWKKAI YKVICKLDSE 720
VPEIFKSPNC LQELLHE 737 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IDA:BHF-UCL.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0060414; P:aorta smooth muscle tissue morphogenesis; ISS:BHF-UCL.
 GO:0055009; P:atrial cardiac muscle tissue morphogenesis; ISS:BHF-UCL.
 GO:0001709; P:cell fate determination; IEA:Compara.
 GO:0021707; P:cerebellar granule cell differentiation; ISS:BHF-UCL.
 GO:0021542; P:dentate gyrus development; ISS:BHF-UCL.
 GO:0021516; P:dorsal spinal cord development; ISS:BHF-UCL.
 GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IEP:BHF-UCL.
 GO:0060214; P:endocardium formation; ISS:BHF-UCL.
 GO:0002194; P:hepatocyte cell migration; IEA:Compara.
 GO:0070365; P:hepatocyte differentiation; IEP:BHF-UCL.
 GO:0072574; P:hepatocyte proliferation; IEA:Compara.
 GO:0001822; P:kidney development; IEP:BHF-UCL.
 GO:0070309; P:lens fiber cell morphogenesis; IEP:BHF-UCL.
 GO:0030324; P:lung development; IEP:BHF-UCL.
 GO:0001946; P:lymphangiogenesis; IDA:BHF-UCL.
 GO:0070858; P:negative regulation of bile acid biosynthetic process; IMP:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; IMP:BHF-UCL.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0045071; P:negative regulation of viral genome replication; IDA:BHF-UCL.
 GO:0021915; P:neural tube development; ISS:BHF-UCL.
 GO:0097150; P:neuronal stem cell maintenance; ISS:BHF-UCL.
 GO:0030910; P:olfactory placode formation; ISS:BHF-UCL.
 GO:0046619; P:optic placode formation involved in camera-type eye formation; ISS:BHF-UCL.
 GO:0043049; P:otic placode formation; ISS:BHF-UCL.
 GO:0031016; P:pancreas development; IEP:BHF-UCL.
 GO:0045737; P:positive regulation of cyclin-dependent protein kinase activity; IDA:BHF-UCL.
 GO:0010595; P:positive regulation of endothelial cell migration; IDA:BHF-UCL.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:BHF-UCL.
 GO:2000979; P:positive regulation of forebrain neuron differentiation; ISS:BHF-UCL.
 GO:0060421; P:positive regulation of heart growth; ISS:BHF-UCL.
 GO:2000179; P:positive regulation of neural precursor cell proliferation; ISS:BHF-UCL.
 GO:0060298; P:positive regulation of sarcomere organization; ISS:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:BHF-UCL.
 GO:0060849; P:regulation of transcription involved in lymphatic endothelial cell fate commitment; IMP:BHF-UCL.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0030240; P:skeletal muscle thin filament assembly; ISS:BHF-UCL.
 GO:0048845; P:venous blood vessel morphogenesis; ISS:BHF-UCL.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; ISS:BHF-UCL.
 GO:0055005; P:ventricular cardiac myofibril development; ISS:BHF-UCL.
 GO:0060412; P:ventricular septum morphogenesis; ISS:BHF-UCL. 
Interpro
 IPR023082; Homeo_prospero_dom.
 IPR009057; Homeodomain-like.
 IPR007738; Prox1. 
Pfam
 PF05044; Prox1 
SMART
  
PROSITE
  
PRINTS