UniProt Accession

 WBP11_MOUSE; Q923D5; O88539; Q3UMD8; Q8VDI0 

Genbank Protein ID

 AK031678; AK041079; AK144968; BC006600; BC021823; AF071186 

Genbank Nucleotide ID

 BAC27508.1; BAC30812.1; BAE26160.1; AAH06600.1; AAH21823.1; AAC34812.1 

Protein Name

 WW domain-binding protein 11 

Protein Synonyms/Alias

 WBP-11; Splicing factor that interacts with PQBP-1 and PP1 

Gene Name

 Wbp11 

Gene Synonyms/Alias

 Sipp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	TSSTKSGKFMNPTDQ	acetylation	[1, 2]
316	RFADMPGKSRKKKKN	acetylation	[2]
325	RKKKKNMKELTPLQA	acetylation	[1]
565	ATATISAKPQITNPK	acetylation	[2, 3, 4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. 

Sequence Annotation

 REGION 1 45 Required for nuclear import.
 REGION 217 221 Interaction with PP1.
 REGION 306 310 Interaction with PP1.
 REGION 633 641 Required for nuclear export.
 MOTIF 455 466 PGR.
 MOD_RES 13 13 N6-acetyllysine (By similarity).
 MOD_RES 181 181 Phosphoserine (By similarity).
 MOD_RES 237 237 Phosphoserine.
 MOD_RES 279 279 Phosphoserine (By similarity).
 MOD_RES 283 283 Phosphoserine (By similarity).
 MOD_RES 353 353 Phosphoserine.
 MOD_RES 361 361 Phosphoserine (By similarity).
 MOD_RES 364 364 Phosphoserine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 641 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016607; C:nuclear speck; IDA:MGI.
 GO:0008599; F:protein phosphatase type 1 regulator activity; IDA:MGI.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IDA:MGI.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR019007; WW_dom-bd_prot_11. 

Pfam

 PF09429; Wbp11 

SMART

  

PROSITE

  

PRINTS