| Tag | Content |
|---|
| CPLM ID | CPLM-015543 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sulfhydryl oxidase 2 |
Protein Synonyms/Alias | Neuroblastoma-derived sulfhydryl oxidase; Quiescin Q6-like protein 1 |
Gene Name | QSOX2 |
Gene Synonyms/Alias | QSCN6L1; SOXN |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 146 | YPTFRYFKAFTKEFT | ubiquitination | [1] | | 246 | TRALDGDKAFLEKLG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. |
Sequence Annotation | DOMAIN 34 178 Thioredoxin.
DOMAIN 421 530 ERV/ALR sulfhydryl oxidase.
NP_BIND 505 512 FAD (By similarity).
ACT_SITE 91 91 Nucleophile (By similarity).
ACT_SITE 94 94 Nucleophile (By similarity).
BINDING 426 426 FAD (By similarity).
BINDING 433 433 FAD (By similarity).
BINDING 437 437 FAD (By similarity).
BINDING 478 478 FAD (By similarity).
BINDING 482 482 FAD (By similarity).
BINDING 527 527 FAD (By similarity).
BINDING 530 530 FAD (By similarity).
MOD_RES 579 579 Phosphoserine.
CARBOHYD 77 77 N-linked (GlcNAc...) (Potential).
CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
CARBOHYD 218 218 N-linked (GlcNAc...) (Potential).
CARBOHYD 266 266 N-linked (GlcNAc...) (Potential).
DISULFID 91 94 Redox-active (By similarity).
DISULFID 418 430 By similarity.
DISULFID 476 479 By similarity.
DISULFID 536 539 By similarity. |
Keyword | Cell membrane; Complete proteome; Disulfide bond; FAD; Flavoprotein; Glycoprotein; Membrane; Nucleus; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 698 AA |
Protein Sequence | MAAAGAAVAR SPGIGAGPAL RARRSPPPRA ARLPRLLVLL AAAAVGPGAG GAARLYRAGE 60
DAVWVLDSGS VRGATANSSA AWLVQFYSSW CGHCIGYAPT WRALAGDVRD WASAIRVAAL 120
DCMEEKNQAV CHDYDIHFYP TFRYFKAFTK EFTTGENFKG PDRELRTVRQ TMIDFLQNHT 180
EGSRPPACPR LDPIQPSDVL SLLDNRGSHY VAIVFESNSS YLGREVILDL IPYESIVVTR 240
ALDGDKAFLE KLGVSSVPSC YLIYPNGSHG LINVVKPLRA FFSSYLKSLP DVRKKSLPLP 300
EKPHKEENSE IVVWREFDKS KLYTVDLESG LHYLLRVELA AHKSLAGAEL KTLKDFVTVL 360
AKLFPGRPPV KKLLEMLQEW LASLPLDRIP YNAVLDLVNN KMRISGIFLT NHIKWVGCQG 420
SRSELRGYPC SLWKLFHTLT VEASTHPDAL VGTGFEDDPQ AVLQTMRRYV HTFFGCKECG 480
EHFEEMAKES MDSVKTPDQA ILWLWKKHNM VNGRLAGHLS EDPRFPKLQW PTPDLCPACH 540
EEIKGLASWD EGHVLTFLKQ HYGRDNLLDT YSADQGDSSE GGTLARGEEE EKRLTPPEVS 600
HGDRDTQSVR PPGALGPRPA LPESLHHSLD GKLQSLDGPG AHKEVGGAAP FLGVDFSSLD 660
MSLCVVLYVA SSLFLMVMYF FFRVRSRRWK VKHHHPAV 698 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0016972; F:thiol oxidase activity; IEA:EC. GO:0045454; P:cell redox homeostasis; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |