| Tag | Content |
|---|
| CPLM ID | CPLM-017838 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cell surface glycoprotein MUC18 |
Protein Synonyms/Alias | Gicerin; Melanoma cell adhesion molecule; Melanoma-associated antigen MUC18; CD146 |
Gene Name | Mcam |
Gene Synonyms/Alias | Muc18 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 607 | ITLPPTRKSEFVVEV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity). |
Sequence Annotation | DOMAIN 24 131 Ig-like V-type 1.
DOMAIN 141 244 Ig-like V-type 2.
DOMAIN 246 332 Ig-like C2-type 1.
DOMAIN 337 426 Ig-like C2-type 2.
DOMAIN 432 512 Ig-like C2-type 3.
MOD_RES 616 616 Phosphoserine (By similarity).
CARBOHYD 58 58 N-linked (GlcNAc...).
CARBOHYD 510 510 N-linked (GlcNAc...).
DISULFID 50 118 By similarity.
DISULFID 163 225 By similarity.
DISULFID 274 322 By similarity.
DISULFID 367 409 By similarity.
DISULFID 454 501 By similarity. |
Keyword | Alternative splicing; Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 648 AA |
Protein Sequence | MGLPKLVCVF LFAACCCCRR AAGVPGEEKQ PVPTPDLVEA EVGSTALLKC GPSRASGNFS 60
QVDWFLIHKE RQILIFRVHQ GKGQREPGEY EHRLSLQDSV ATLALSHVTP HDERMFLCKS 120
KRPRLQDHYV ELQVFKAPEE PTIQANVVGI HVDRQELREV ATCVGRNGYP IPQVLWYKNS 180
LPLQEEENRV HIQSSQIVES SGLYTLKSVL SARLVKEDKD AQFYCELSYR LPSGNHMKES 240
KEVTVPVFYP AEKVWVEVEP VGLLKEGDHV TIRCLTDGNP QPHFTINKKD PSTGEMEEES 300
TDENGLLSLE PAEKHHSGLY QCQSLDLETT ITLSSDPLEL LVNYVSDVQV NPTAPEVQEG 360
ESLTLTCEAE SNQDLEFEWL RDKTGQLLGK GPVLQLNNVR REAGGRYLCM ASVPRVPGLN 420
RTQLVSVGIF GSPWMALKER KVWVQENAVL NLSCEASGHP QPTISWNVNG SATEWNPDPQ 480
TVVSTLNVLV TPELLETGAE CTASNSLGSN TTTIVLKLVT LTTLIPDSSQ TTGLSTLTVS 540
PHTRANSTST EKKLPQPESK GVVIVAVIVC TLVLAVLGAA LYFFYKKGKL PCGRSGKQEI 600
TLPPTRKSEF VVEVKSDKLP EEMALLQGSN GDKRAPGDQG EKYIDLRH 648 |
Gene Ontology | GO:0009897; C:external side of plasma membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; ISO:MGI. GO:0003094; P:glomerular filtration; IEA:Compara. GO:0007157; P:heterophilic cell-cell adhesion; ISO:MGI. GO:0061042; P:vascular wound healing; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |