UniProt Accession

 YCGR_ECOLI; P76010; Q9R7N3 

Genbank Protein ID

 U00096; AP009048 

Genbank Nucleotide ID

 AAC74278.1; BAA36052.2 

Protein Name

 Flagellar brake protein YcgR 

Protein Synonyms/Alias

 Cyclic di-GMP binding protein YcgR 

Gene Name

 ycgR 

Gene Synonyms/Alias

 b1194; JW1183 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
25	GVLRDLHKAAIPLRL	acetylation	[1]
195	LISISERKVIDGKNE	acetylation	[1]
200	ERKVIDGKNETITTP	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. When bound to c-di-GMP it binds to elements of the flagellar motor (MotA (PubMed:20303158) and/or FliG and FliM (PubMed:20346719), binding to FliM also occurs in the absence of c-di-GMP), causing the motor to slow down. Thus, increasing levels of c-di-GMP lead to decreased motility. Probably binds 1 c-di-GMP dimer per subunit. 

Sequence Annotation

 DOMAIN 112 230 PilZ.  

Keyword

 Bacterial flagellum; c-di-GMP; Complete proteome; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
 GO:0035438; F:cyclic-di-GMP binding; IDA:UniProtKB.
 GO:0010181; F:FMN binding; IEA:InterPro.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0060286; P:flagellar cell motility; IMP:UniProtKB.
 GO:0071945; P:regulation of bacterial flagellum cell motility by regulation of motor speed; IGI:UniProtKB. 

Interpro

 IPR009875; PilZ_domain.
 IPR012349; Split_barrel_FMN-bd.
 IPR023787; T3SS_YcgR.
 IPR009926; T3SS_YcgR_N. 

Pfam

 PF07238; PilZ
 PF07317; YcgR 

SMART

  

PROSITE

  

PRINTS