CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003684
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Putative male-specific lethal-3 protein-like 2 
Protein Synonyms/Alias
 MSL3-like 2; Male-specific lethal-3 homolog 2; Male-specific lethal-3 homolog pseudogene 1 
Gene Name
 MSL3P1 
Gene Synonyms/Alias
 MSL3L2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106LEIPEVLKRQLEDDCubiquitination[1]
180EKNIDLCKEMVDGLRubiquitination[1]
220SKVFLAIKESATNTNubiquitination[1]
232NTNRSQEKLSPSLRLubiquitination[1]
288ANCDRLSKSSTSPQPubiquitination[1]
315KLFLHLEKKTPVHSRacetylation[2]
315KLFLHLEKKTPVHSRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be involved in chromatin remodeling and transcriptional regulation (By similarity). 
Sequence Annotation
 DOMAIN 32 90 Chromo.
 DOMAIN 93 441 MRG.  
Keyword
 Chromatin regulator; Complete proteome; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 447 AA 
Protein Sequence
MPDRACAVGS VARALSRSRR YVCARDADAS RRRRRPFNYG LSIEEKNEND ENSLSSSSDS 60
SEDKDEKISE ECDIEEKTEV KEEPELQTKR EMEERTVTLE IPEVLKRQLE DDCYYINRRK 120
RLVQLPCHTN IITILESYVK HFAISAAFSA NERPRHHHAM PHASMNVPYI PAEKNIDLCK 180
EMVDGLRITF DYTLPLVLLY PYEQAQYKKV TASKVFLAIK ESATNTNRSQ EKLSPSLRLL 240
NPSRPQSTES QSTSGEPATP KRRKAEPQAV QSLRRSSPHT ANCDRLSKSS TSPQPKRWQQ 300
DMSTSVPKLF LHLEKKTPVH SRSSSPTLTP SQEGSPVFAG FEGRRTNEIN EVLSWKLVPD 360
NYPPGDQPPP PSYIYGAQHL LRLFVKLPEI LGKMSFTEKN LKALLKHFDL FVRFLAEYHD 420
DFFPESAYVA ASEVHYSTRN PQAVNKC 447 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR008676; MRG.
 IPR026541; MRG_dom. 
Pfam
 PF05712; MRG 
SMART
  
PROSITE
 PS00598; CHROMO_1
 PS50013; CHROMO_2
 PS51640; MRG 
PRINTS