| Tag | Content |
|---|
| CPLM ID | CPLM-022871 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA repair protein REV1 |
Protein Synonyms/Alias | Alpha integrin-binding protein 80; AIBP80; Rev1-like terminal deoxycytidyl transferase |
Gene Name | REV1 |
Gene Synonyms/Alias | REV1L |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 28 | YMAAKVQKLEEQFRS | ubiquitination | [1] | | 119 | EWIVESIKAGRLLSY | ubiquitination | [1] | | 134 | IPYQLYTKQSSVQKG | ubiquitination | [1] | | 140 | TKQSSVQKGLSFNPV | ubiquitination | [1] | | 678 | LQYMTMAKLQKEFGP | ubiquitination | [1] | | 770 | GAPVETAKFGGHGIC | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. |
Sequence Annotation | DOMAIN 44 131 BRCT.
DOMAIN 419 653 UmuC.
NP_BIND 423 427 dCTP binding (By similarity).
NP_BIND 510 516 dCTP binding (By similarity).
REGION 352 362 Interaction with target DNA (By
REGION 653 656 Interaction with target DNA (By
REGION 709 717 Interaction with target DNA (By
REGION 1150 1249 Protein interaction domain; mediates
MOTIF 1071 1078 Nuclear localization signal (Potential).
METAL 423 423 Magnesium 1 (By similarity).
METAL 423 423 Magnesium 2 (By similarity).
METAL 570 570 Magnesium 1 (By similarity).
METAL 571 571 Magnesium 1 (By similarity).
BINDING 357 357 dCTP (By similarity).
BINDING 522 522 dCTP (By similarity).
BINDING 570 570 dCTP (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; DNA damage; DNA repair; DNA synthesis; DNA-binding; Magnesium; Metal-binding; Nucleotidyltransferase; Nucleus; Polymorphism; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1251 AA |
Protein Sequence | MRRGGWRKRA ENDGWETWGG YMAAKVQKLE EQFRSDAAMQ KDGTSSTIFS GVAIYVNGYT 60
DPSAEELRKL MMLHGGQYHV YYSRSKTTHI IATNLPNAKI KELKGEKVIR PEWIVESIKA 120
GRLLSYIPYQ LYTKQSSVQK GLSFNPVCRP EDPLPGPSNI AKQLNNRVNH IVKKIETENE 180
VKVNGMNSWN EEDENNDFSF VDLEQTSPGR KQNGIPHPRG STAIFNGHTP SSNGALKTQD 240
CLVPMVNSVA SRLSPAFSQE EDKAEKSSTD FRDCTLQQLQ QSTRNTDALR NPHRTNSFSL 300
SPLHSNTKIN GAHHSTVQGP SSTKSTSSVS TFSKAAPSVP SKPSDCNFIS NFYSHSRLHH 360
ISMWKCELTE FVNTLQRQSN GIFPGREKLK KMKTGRSALV VTDTGDMSVL NSPRHQSCIM 420
HVDMDCFFVS VGIRNRPDLK GKPVAVTSNR GTGRAPLRPG ANPQLEWQYY QNKILKGKAA 480
DIPDSSLWEN PDSAQANGID SVLSRAEIAS CSYEARQLGI KNGMFFGHAK QLCPNLQAVP 540
YDFHAYKEVA QTLYETLASY THNIEAVSCD EALVDITEIL AETKLTPDEF ANAVRMEIKD 600
QTKCAASVGI GSNILLARMA TRKAKPDGQY HLKPEEVDDF IRGQLVTNLP GVGHSMESKL 660
ASLGIKTCGD LQYMTMAKLQ KEFGPKTGQM LYRFCRGLDD RPVRTEKERK SVSAEINYGI 720
RFTQPKEAEA FLLSLSEEIQ RRLEATGMKG KRLTLKIMVR KPGAPVETAK FGGHGICDNI 780
ARTVTLDQAT DNAKIIGKAM LNMFHTMKLN ISDMRGVGIH VNQLVPTNLN PSTCPSRPSV 840
QSSHFPSGSY SVRDVFQVQK AKKSTEEEHK EVFRAAVDLE ISSASRTCTF LPPFPAHLPT 900
SPDTNKAESS GKWNGLHTPV SVQSRLNLSI EVPSPSQLDQ SVLEALPPDL REQVEQVCAV 960
QQAESHGDKK KEPVNGCNTG ILPQPVGTVL LQIPEPQESN SDAGINLIAL PAFSQVDPEV 1020
FAALPAELQR ELKAAYDQRQ RQGENSTHQQ SASASVPKNP LLHLKAAVKE KKRNKKKKTI 1080
GSPKRIQSPL NNKLLNSPAK TLPGACGSPQ KLIDGFLKHE GPPAEKPLEE LSASTSGVPG 1140
LSSLQSDPAG CVRPPAPNLA GAVEFNDVKT LLREWITTIS DPMEEDILQV VKYCTDLIEE 1200
KDLEKLDLVI KYMKRLMQQS VESVWNMAFD FILDNVQVVL QQTYGSTLKV T 1251 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0003684; F:damaged DNA binding; TAS:ProtInc. GO:0017125; F:deoxycytidyl transferase activity; IEA:Compara. GO:0003887; F:DNA-directed DNA polymerase activity; TAS:Reactome. GO:0000287; F:magnesium ion binding; IEA:InterPro. GO:0006260; P:DNA replication; TAS:ProtInc. GO:0042276; P:error-prone translesion synthesis; TAS:UniProtKB. GO:0009411; P:response to UV; IDA:UniProtKB. |
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