CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014617
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peptidyl-prolyl cis-trans isomerase FKBP5 
Protein Synonyms/Alias
 PPIase FKBP5; 51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; FK506-binding protein 5; FKBP-5; Rotamase 
Gene Name
 Fkbp5 
Gene Synonyms/Alias
 Fkbp51 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
352GLDSANEKGLYRRGEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP (By similarity). 
Sequence Annotation
 DOMAIN 50 138 PPIase FKBP-type 1.
 DOMAIN 165 251 PPIase FKBP-type 2.
 REPEAT 268 301 TPR 1.
 REPEAT 317 350 TPR 2.
 REPEAT 351 384 TPR 3.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 444 444 Phosphoserine (By similarity).  
Keyword
 Acetylation; Chaperone; Complete proteome; Cytoplasm; Isomerase; Nucleus; Phosphoprotein; Reference proteome; Repeat; Rotamase; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 456 AA 
Protein Sequence
MTTDEGTSNN GENPAATMTE QGEDITTKKD RGVLKIVKRV GTSDEAPMFG DKVYVHYKGM 60
LSDGKKFDSS HDRKKPFAFS LGQGQVIKAW DIGVSTMKKG EICHLLCKPE YAYGSAGHLQ 120
KIPSNATLFF EIELLDFKGE DLFEDSGVIR RIKRKGEGYS NPNEGATVKV HLEGCCGGRT 180
FDCRDVVFVV GEGEDHDIPI GIDKALVKMQ REEQCILYLG PRYGFGEAGK PKFGIDPNAE 240
LMYEVTLKSF EKAKESWEMD TKEKLTQAAI VKEKGTVYFK GGKYTQAVIQ YRKIVSWLEM 300
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYNKAVECC DKALGLDSAN EKGLYRRGEA 360
QLLMNDFESA KGDFEKVLAV NPQNRAARLQ ISMCQRKAKE HNERDRRVYA NMFKKFAERD 420
AKEEASKAGS KKAVEGAAGK QHESQAMEEG KAKGHV 456 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; ISS:UniProtKB.
 GO:0061077; P:chaperone-mediated protein folding; ISS:UniProtKB. 
Interpro
 IPR023114; Elongated_TPR_rpt_dom.
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00254; FKBP_C
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50059; FKBP_PPIASE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS