CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016712
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dedicator of cytokinesis protein 2 
Protein Synonyms/Alias
 Protein Hch 
Gene Name
 Dock2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
863ILLPVITKELKELLEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. 
Sequence Annotation
 DOMAIN 8 69 SH3.
 DOMAIN 423 607 DHR-1.
 DOMAIN 1210 1621 DHR-2.
 MOD_RES 304 304 N6-acetyllysine (By similarity).
 MOD_RES 588 588 Phosphoserine (By similarity).
 MOD_RES 593 593 Phosphoserine (By similarity).
 MOD_RES 738 738 N6-acetyllysine (By similarity).
 MOD_RES 1683 1683 Phosphoserine (By similarity).
 MOD_RES 1704 1704 Phosphoserine.
 MOD_RES 1729 1729 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1828 AA 
Protein Sequence
MAPWRKTDKE RHGVAIYNFQ GSEAQHLTLQ IGDVVRIQET CGDWYRGYLI KHKLSQGIFP 60
TSFIHLKEVT VEKRRNIENI IPAEIPLAQE VTTTLWEWGS IWKQLYVASK KERFLQVQSM 120
MYDLMEWRSQ LLSGTLPKDE LKELKQKVTS KIDYGNKILE LDLIVRDEDG NILDPDKTSV 180
ISLFHAHEEA TYKITERIKE EMSKDQPDYG VYSRISSSPT HSLYVFVRNF VCRIGEDAEL 240
FMSLYDPHKQ TVISENYLVR WGSKGFPKEI EMLNNLKVVF TDLGNKDLNR DKIFLICQIV 300
RIGKMDLKDI NAKKCTQGLR RPFGVAVMDI TDIIKGKAES DEEKQHFIPF HPVSAENDFL 360
HSLLGKVIAS KGDSGGQGLW VTMKMLVGDI IQIRKDYPHL VDRTTVVARK LGFPEIIMPG 420
DVRNDIYITL LQGDFDKYTK TTQRNVEVIM CVCTEDGKVL PNAICVGAGD KAMNEYHSVV 480
YYQVKQPRWM ETVKVAVPIE DMQRIHLRFM FRHRSSLESK DKGEKNFAMS YVKLMKEDGT 540
TLHDGYHELV VLKGDSKKME DASAYLTLPS YRHPVENKGA TLSRSSSSVG GLSVSSRDVF 600
SISTLVCSTK LTQNVGLLGL LKWRMKPQLL QENLEKLKIV DGEEVVKFLQ DTLDALFNIM 660
MEHSQSNEYD ILVFDALIYI IGLIADRKFQ HFNTVLEAYI QQHFSATLAY KKLMTVLKTY 720
LDTSSRGEQC EPILRTLKAL EYVFKFIVRS RTLFSQLYEG KEQMEFEESM RRLFESINNL 780
MKSQYKTTIL LQVAALKYIP SVLHDVETVF DAKLLSQLLY EFYTCIPPVK LQKQKVQSMN 840
EIVQSNLFKK QECRDILLPV ITKELKELLE QRDDGQHQAE KKHCVELLNS ILEVLSCQDA 900
AFTYDHIQEI MVQLLRTVNR TVITMGRDHA LISHFVACMT AILDQMGDQH YSFYIETFQT 960
SSDLVDFLME TFIMFKDLIG KNVYPGDWMA MSMVQNRVFL RAINKFAETM NQKFLEHTSF 1020
EFQLWNNYFH LAVAFITQDS LQLEQFTHAK YNKILNKYGD MRRLIGFSIR DMWYKLGQNK 1080
ICFIPGMVGP ILEMTLIPEA ELRKATIPIF FDMMLCEYQR TGAFKKFENE IILKLDHEVE 1140
GGRGDEQYMQ LLESILMECT AEHPTIAKSV ENFVSLVKGL LEKLLDYRGV MTDESKDNRM 1200
SCTVNLLNFY KDNNREEMYI RYLYKLRDLH LDCENYTEAA YTLLLHTWLL KWSDEQCASQ 1260
VMQTGQQHPQ THRQLKETLY ETIIGYFDKG KMWEEAISLC KELAEQYEME IFDYELLSQN 1320
LTQQAKFYEN IMKILRTKPD YFAVGYYGQG FPSFLRNKVF IYRGKEYERR EDFQMQLLSQ 1380
FPNAEKMNTT SAPGDDVRNA PGQYIQCFTV QPVLDEHPRF KNKPVPDQII NFYKSNYVQK 1440
FHYSRPVRRG KVDPENEFAS MWIERTSFLT AYKLPGILRW FEVVHMSQTT ISPLENAIET 1500
MSTVNEKILM MINQYQSDES LPINPLSMLL NGIVDPAVMG GFAKYEKAFF TEEYSREHPE 1560
DQDKLSHLKD LIAWQIPFLG AGIKIHEKRV SDNLRPFHDR MEECFKNLKM KVEKEYGVRE 1620
MPDFEDRRVG RPRSMLRSYR QMSVISLASM HSDCSTPSKV PAESFDLESA PPKTPKVEEE 1680
PISPGSTLPE VKLRRSKKRT KRSSVVFADE KAATESDLKR LSRKQEFMSD TNLSEHAAIP 1740
ARVSILSQMS FASQSMPTIP ALTLSVAGVP GLDEANTSPR LSQTFFQVSD GDKKTLKKKK 1800
VNQFFKTMLA SKSSEESKQI PDFLSTNM 1828 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0030675; F:Rac GTPase activator activity; IMP:MGI.
 GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
 GO:0042608; F:T cell receptor binding; ISS:UniProtKB.
 GO:0046633; P:alpha-beta T cell proliferation; IMP:MGI.
 GO:0006935; P:chemotaxis; IMP:MGI.
 GO:0007010; P:cytoskeleton organization; IDA:MGI.
 GO:0001768; P:establishment of T cell polarity; IMP:MGI.
 GO:0001771; P:immunological synapse formation; IMP:MGI.
 GO:0044351; P:macropinocytosis; IMP:UniProtKB.
 GO:0001766; P:membrane raft polarization; IMP:MGI.
 GO:0002277; P:myeloid dendritic cell activation involved in immune response; IMP:UniProtKB.
 GO:0045060; P:negative thymic T cell selection; IMP:MGI.
 GO:0050766; P:positive regulation of phagocytosis; IMP:UniProtKB.
 GO:0035022; P:positive regulation of Rac protein signal transduction; IC:MGI.
 GO:0045059; P:positive thymic T cell selection; IMP:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR026799; DOCK_A.
 IPR010703; DOCK_C.
 IPR001452; SH3_domain. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2
 PF00018; SH3_1 
SMART
 SM00326; SH3 
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2
 PS50002; SH3 
PRINTS