CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004732
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide-binding protein G(t) subunit alpha-2 
Protein Synonyms/Alias
 Transducin alpha-2 chain 
Gene Name
 GNAT2 
Gene Synonyms/Alias
 GNATC 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51SGKSTIVKQMKIIHQubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. 
Sequence Annotation
 NP_BIND 40 47 GTP (By similarity).
 NP_BIND 175 181 GTP (By similarity).
 NP_BIND 200 204 GTP (By similarity).
 NP_BIND 269 272 GTP (By similarity).
 METAL 47 47 Magnesium (By similarity).
 METAL 181 181 Magnesium (By similarity).
 BINDING 326 326 GTP; via amide nitrogen (By similarity).
 MOD_RES 178 178 ADP-ribosylarginine; by cholera toxin (By
 MOD_RES 351 351 ADP-ribosylcysteine; by pertussis toxin
 LIPID 2 2 N-myristoyl glycine (By similarity).  
Keyword
 ADP-ribosylation; Complete proteome; GTP-binding; Lipoprotein; Magnesium; Metal-binding; Myristate; Nucleotide-binding; Polymorphism; Reference proteome; Sensory transduction; Transducer; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MGSGASAEDK ELAKRSKELE KKLQEDADKE AKTVKLLLLG AGESGKSTIV KQMKIIHQDG 60
YSPEECLEFK AIIYGNVLQS ILAIIRAMTT LGIDYAEPSC ADDGRQLNNL ADSIEEGTMP 120
PELVEVIRRL WKDGGVQACF ERAAEYQLND SASYYLNQLE RITDPEYLPS EQDVLRSRVK 180
TTGIIETKFS VKDLNFRMFD VGGQRSERKK WIHCFEGVTC IIFCAALSAY DMVLVEDDEV 240
NRMHESLHLF NSICNHKFFA ATSIVLFLNK KDLFEEKIKK VHLSICFPEY DGNNSYDDAG 300
NYIKSQFLDL NMRKDVKEIY SHMTCATDTQ NVKFVFDAVT DIIIKENLKD CGLF 354 
Gene Ontology
 GO:0005834; C:heterotrimeric G-protein complex; NAS:UniProtKB.
 GO:0001917; C:photoreceptor inner segment; IDA:UniProtKB.
 GO:0042622; C:photoreceptor outer segment membrane; ISS:UniProtKB.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0008020; F:G-protein coupled photoreceptor activity; NAS:UniProtKB.
 GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; NAS:UniProtKB.
 GO:0003924; F:GTPase activity; IBA:RefGenome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:RefGenome.
 GO:0050908; P:detection of light stimulus involved in visual perception; IMP:UniProtKB.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0007602; P:phototransduction; NAS:UniProtKB.
 GO:0009642; P:response to light intensity; IEA:Compara.
 GO:0046549; P:retinal cone cell development; IEA:Compara. 
Interpro
 IPR001408; Gprotein_alpha_I.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00503; G-alpha 
SMART
 SM00275; G_alpha 
PROSITE
  
PRINTS
 PR00318; GPROTEINA.
 PR00441; GPROTEINAI.