CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ELAV-like protein 2 
Protein Synonyms/Alias
  
Gene Name
 ELAVL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
102SCKLVRDKITGQSLGubiquitination[1]
123IDPKDAEKAINTLNGubiquitination[1]
237FANNPSQKTNQAILSubiquitination[1, 2, 3, 4, 5]
343IRDFNTNKCKGFGFVubiquitination[6]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 387 AA 
Protein Sequence
MAVRLCDVAS LLRSGSWAAE PWTGVIAAME TQLSNGPTCN NTANGPTTIN NNCSSPVDSG 60
NTEDSKTNLI VNYLPQNMTQ EELKSLFGSI GEIESCKLVR DKITGQSLGY GFVNYIDPKD 120
AEKAINTLNG LRLQTKTIKV SYARPSSASI RDANLYVSGL PKTMTQKELE QLFSQYGRII 180
TSRILVDQVT GISRGVGFIR FDKRIEAEEA IKGLNGQKPP GATEPITVKF ANNPSQKTNQ 240
AILSQLYQSP NRRYPGPLAQ QAQRFRLDNL LNMAYGVKRF SPMTIDGMTS LAGINIPGHP 300
GTGWCIFVYN LAPDADESIL WQMFGPFGAV TNVKVIRDFN TNKCKGFGFV TMTNYDEAAM 360
AIASLNGYRL GDRVLQVSFK TNKTHKA 387 
Gene Ontology
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR006548; ELAD_HUD_SF.
 IPR002343; Hud_Sxl_RNA.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS
 PR00961; HUDSXLRNA.