| Tag | Content |
|---|
| CPLM ID | CPLM-014571 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adapter molecule crk |
Protein Synonyms/Alias | Proto-oncogene c-Crk; p38 |
Gene Name | Crk |
Gene Synonyms/Alias | Crko |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 253 | RVPNAYDKTALALEV | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. |
Sequence Annotation | DOMAIN 13 118 SH2.
DOMAIN 132 192 SH3 1.
DOMAIN 237 296 SH3 2.
MOD_RES 41 41 Phosphoserine.
MOD_RES 42 42 Phosphothreonine.
MOD_RES 74 74 Phosphoserine (By similarity).
MOD_RES 83 83 Phosphoserine (By similarity).
MOD_RES 221 221 Phosphotyrosine; by ABL1.
MOD_RES 239 239 Phosphotyrosine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Proto-oncogene; Reference proteome; Repeat; SH2 domain; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 304 AA |
Protein Sequence | MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 60
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVAR 120
SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG 180
MIPVPYVEKY RPASASVSAL IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA 240
RVIQKRVPNA YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD 300
EDFS 304 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0045309; F:protein phosphorylated amino acid binding; IDA:MGI. GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB. GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB. GO:0035020; P:regulation of Rac protein signal transduction; IEA:Compara. GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |