CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012874
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fer-1-like protein 6 
Protein Synonyms/Alias
  
Gene Name
 FER1L6 
Gene Synonyms/Alias
 C8orfK23 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
578YLPFEAKKPCVYFISubiquitination[1, 2]
1304TFELFRGKSTEDDHGmethylation[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
  
Sequence Annotation
 DOMAIN 70 160 C2 1.
 DOMAIN 230 345 C2 2.
 DOMAIN 813 918 C2 3.
 DOMAIN 1047 1081 C2 4.
 DOMAIN 1343 1441 C2 5.
 DOMAIN 1583 1712 C2 6.  
Keyword
 Complete proteome; Membrane; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1857 AA 
Protein Sequence
MFGLKVKKKR NKAEKGLILA NKAAKDSQGD TEALQEEPSH QEGPRGDLVH DDASIFPVPS 60
ASPKRRSKLL TKIHDGEVRS QNYQIAITIT EARQLVGENI DPVVTIEIGD EKKQSTVKEG 120
TNSPFYNEYF VFDFIGPQVH LFDKIIKISV FHHKLIGSVL IGSFKVDLGT VYNQPGHQFC 180
NKWALLTDPG DIRTGTKGYL KCDISVMGKG DVLKTSPKTS DTEEPIEKNL LIPNGFPLER 240
PWARFYVRLY KAEGLPKMNS SIMANVTKAF VGDSKDLVDP FVEVSFAGQM GRTTVQKNCA 300
DPVWHEQVIF KEMFPPLCRR VKIQVWDEGS MNDVALATHF IDLKKISNEQ DGDKGFLPTF 360
GPAWINLYGS PRNHSLMDDY QEMNEGFGEG VSFRGRILVE IAVEILSGRA QESKFSKALK 420
ELKLPSKDKD SKSSKGKDKA DKTEDGKSQQ ASNKTNSTEV EVESFDVPPE IVPEKNEEFL 480
LFGAFFEATM IDRKIGDKPI SFEVSIGNFG NLIDGGSHHG SKKSAESAEE DLLPLLHEGQ 540
GDVAHDVPIP MASTTHPEKP LVTEGNRNYN YLPFEAKKPC VYFISSWGDQ TFRLHWSNML 600
EKMADFLEES IEEVRELIKI SQEAPEEKMK TVLSDFISRS SAFISEAEKK PKMLNQTTLD 660
KKRLTLCWQE LEAMCKEAKG IIQQQKKKLS VDEMIHEAQN FVEKIRFLVD EPQHTIPDVF 720
IWMLSNNRRV AYARIASKDL LYSPVAGQMG KHCGKIKTHF LKPPGKRPAG WSVQAKVDVY 780
LWLGSIKHAS AILDNLPVGY EAEMSSKGAG TNHPPSNLLY QEQHVFQLRA HMYQARGLIA 840
ADSNGLSDPF AKVTFLSHCQ TTKIISQTLS PTWNQMLLFN DLVLHGDVKE LAESPPLVVV 900
ELYDSDAVGK PEYLGATVAA PVVKLADQDY EPPRLCYHPI FCGNLSGGDL LAVFELLQVP 960
PSGLQGLPPV EPPDITQIYP VPANIRPVLS KYRVEVLFWG VREMKKVQLL SVDRPQALIE 1020
CGGQGVKSCV IQSYKNNPNF SIQADAFEVE LPENELLHPP LSICVVDWRA FGRSTLVGTY 1080
TINYLKQFLC KLREPLAPIT QVDGTQPGHD ISDSLTATES SGAHSSSQDP PADHIYVDVE 1140
PPPTVVPDSA QAQPAILVDV PDSSPMLEPE HTPVAQEPPK DGKPKDPRKP SRRSTKRRKR 1200
TIADESAENV IDWWSKYYAS LKKAQKAKER NPKGKKGNTE AKPDEVVVDI EDGPKKKKDK 1260
MLKKKPKDDG IPNLAILQIY DGDLESEFNN FEDWVKTFEL FRGKSTEDDH GLDGDRVIGK 1320
FKGSFCIYKS PQDSSSEDSG QLRIQQGIPP NHPVTVLIRV YIVAAFNLSP ADPDGKSDPY 1380
IVIKLGKTEI KDRDKYIPKQ LNPVFGRSFE IQATFPKESL LSILIYDHDM IGTDDLIGET 1440
KIDLENRFYS KHRAICGLQS QYEIEGYNAW RDTSKPTEIL TKLCKDNKLD GPYFHPGKIQ 1500
IGNQVFSGKT IFTEEDTDET VESYEHLALK VLHSWEDIPE VGCRLVPEHI ETRPLYHKDK 1560
PGMEQGRLQM WVDMFPKDMP QPGPPVDISP RRPKGYELRV TIWNTEDVIL EDENIFTGQK 1620
SSDIYVKGWL KGLEDDKQET DVHYNSLTGE GNFNWRFLFP FQYLPAEKQM VITKRENIFS 1680
LEKMECKTPA VLVLQVWDFE RLSSDDFLGT LEMNLNSFPR AAKSAKACDL AKFENASEET 1740
KISIFQQKRV RGWWPFSKSK ELTGKVEAEF HLVTAEEAEK NPVGKARKEP EPLAKPNRPD 1800
TSFSWFMSPF KCLYYLIWKN YKKYIIIAFI LIILIIFLVL FIYTLPGAIS RRIVVGS 1857 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR012968; FerIin-domain.
 IPR012561; Ferlin_B-domain. 
Pfam
 PF00168; C2
 PF08150; FerB
 PF08151; FerI 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2 
PRINTS