CPLM-009683

Genbank Nucleotide ID

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Protein Synonyms/Alias

Adenylate cyclase-stimulating G alpha protein

Mus musculus (Mouse)

Position	Peptide	Type	References
8	MGCLGNSKTEDQRNE	ubiquitination	[1]
17	EDQRNEEKAQREANK	ubiquitination	[1]
58	SGKSTIVKQMRILHV	ubiquitination	[1]
96	ATKVQDIKNNLKEAI	ubiquitination	[1]
186	LDKIDVIKQADYVPS	ubiquitination	[1]
211	TSGIFETKFQVDKVN	ubiquitination	[1]
216	ETKFQVDKVNFHMFD	ubiquitination	[1]
300	KQDLLAEKVLAGKSK	ubiquitination	[1]
307	KVLAGKSKIEDYFPE	ubiquitination	[1]
338	DPRVTRAKYFIRDEF	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli.

NP_BIND 47 54 GTP (By similarity).
NP_BIND 198 204 GTP (By similarity).
NP_BIND 223 227 GTP (By similarity).
NP_BIND 292 295 GTP (By similarity).
METAL 54 54 Magnesium (By similarity).
METAL 204 204 Magnesium (By similarity).
BINDING 366 366 GTP; via amide nitrogen (By similarity).
MOD_RES 51 51 Phosphoserine.
MOD_RES 352 352 Phosphoserine (By similarity).
LIPID 2 2 N-palmitoyl glycine (By similarity).
LIPID 3 3 S-palmitoyl cysteine.
CROSSLNK 300 300 Glycyl lysine isopeptide (Lys-Gly)

Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; GTP-binding; Isopeptide bond; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Transducer; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030425; C:dendrite; IDA:MGI.
GO:0005834; C:heterotrimeric G-protein complex; ISA:MGI.
GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0003924; F:GTPase activity; ISA:MGI.
GO:0035255; F:ionotropic glutamate receptor binding; IBA:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0031852; F:mu-type opioid receptor binding; IBA:RefGenome.
GO:0004871; F:signal transducer activity; IBA:RefGenome.
GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IGI:MGI.
GO:0051216; P:cartilage development; IMP:MGI.
GO:0006306; P:DNA methylation; IMP:MGI.
GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI.
GO:0035116; P:embryonic hindlimb morphogenesis; IMP:MGI.
GO:0001958; P:endochondral ossification; IMP:MGI.
GO:0006112; P:energy reserve metabolic process; IMP:MGI.
GO:0071514; P:genetic imprinting; IMP:MGI.
GO:0035264; P:multicellular organism growth; IMP:MGI.
GO:0045669; P:positive regulation of osteoblast differentiation; IMP:MGI.
GO:0045672; P:positive regulation of osteoclast differentiation; IMP:MGI.
GO:0040032; P:post-embryonic body morphogenesis; IMP:MGI.
GO:0042493; P:response to drug; IMP:MGI.
GO:0007606; P:sensory perception of chemical stimulus; IBA:RefGenome.
GO:0043588; P:skin development; IMP:MGI.
GO:0001894; P:tissue homeostasis; IMP:MGI.

IPR000367; Gprotein_alpha_S.
IPR001019; Gprotein_alpha_su.
IPR011025; GproteinA_insert.
IPR027417; P-loop_NTPase.

PR00318; GPROTEINA.
PR00443; GPROTEINAS.