UniProt Accession

 RIR2B_HUMAN; Q7LG56; Q17R22; Q75PQ6; Q75PQ7; Q75PY8; Q75PY9; Q86YE3; Q9NPD6; Q9NTD8; Q9NUW3 

Genbank Protein ID

 AB036063; AB036532; AB163437; AB163438; AB166669; AB166670; AB166671; AK001965; AL137348; DQ027001; AP001328; AP002907; BC042468; BC108261; BC117496; BC130628 

Genbank Nucleotide ID

 BAA92434.1; BAA92493.1; BAD11774.1; BAD11775.1; BAD12265.1; BAD12266.1; BAD12267.1; BAA92005.1; CAB70703.2; AAY29059.1; AAH42468.1; AAI08262.1; AAI17497.1; AAI30629.1 

Protein Name

 Ribonucleoside-diphosphate reductase subunit M2 B 

Protein Synonyms/Alias

 TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2 

Gene Name

 RRM2B 

Gene Synonyms/Alias

 P53R2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
28	DTNESEIKSNEEPLL	ubiquitination	[1]
166	IETMPYVKKKADWAL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. 

Sequence Annotation

 ACT_SITE 138 138 By similarity.
 METAL 100 100 Iron 1.
 METAL 131 131 Iron 1.
 METAL 131 131 Iron 2.
 METAL 134 134 Iron 1.
 METAL 194 194 Iron 2.
 METAL 228 228 Iron 2.
 METAL 231 231 Iron 2.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; DNA damage; DNA repair; DNA replication; Iron; Metal-binding; Neuropathy; Nucleus; Oxidoreductase; Polymorphism; Progressive external ophthalmoplegia; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 351 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC.
 GO:0046914; F:transition metal ion binding; IEA:InterPro.
 GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro.
 GO:0009200; P:deoxyribonucleoside triphosphate metabolic process; IEA:Compara.
 GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0006264; P:mitochondrial DNA replication; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
 GO:0003014; P:renal system process; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara. 

Interpro

 IPR009078; Ferritin-like_SF.
 IPR012348; RNR-rel.
 IPR000358; RNR_small. 

Pfam

 PF00268; Ribonuc_red_sm 

SMART

  

PROSITE

 PS00368; RIBORED_SMALL 

PRINTS