CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039980
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase 
Protein Synonyms/Alias
  
Gene Name
 JAK2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
613SALDSQRKLQFYEDRubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 983 AA 
Protein Sequence
MSYLFAQWRH DFVHGWIKVP VTHETQEECL GMAVLDMMRI AKENDQTPLA IYNSISYKTF 60
LPKCIRAKIQ DYHILTRKRI RYRFRRFIQQ FSQCKATARN LKLKYLINLE TLQSAFYTEK 120
FEVKEPGSGP SGEEIFATII ITGNGGIQWS RGKHKESETL TEQDLQLYCD FPNIIDVSIK 180
QANQEGSNES RVVTIHKQDG KNLEIELSSL REALSFVSLI DGYYRLTADA HHYLCKEVAP 240
PAVLENIQSN CHGPISMDFA ISKLKKAGNQ TGLYVLRCSP KDFNKYFLTF AVERENVIEY 300
KHCLITKNEN EEYNLSGTKK NFSSLKDLLN CYQMETVRSD NIIFQFTKCC PPKPKDKSNL 360
LVFRTNGVSD VPTSPTLQRP THMNQMVFHK IRNEDLIFNE SLGQGTFTKI FKGVRREVGD 420
YGQLHETEVL LKVLDKAHRN YSESFFEAAS MMSKLSHKHL VLNYGVCVCG DENILVQEFV 480
KFGSLDTYLK KNKNCINILW KLEVAKQLAW AMHFLEENTL IHGNVCAKNI LLIREEDRKT 540
GNPPFIKLSD PGISITVLPK DILQERIPWV PPECIENPKN LNLATDKWSF GTTLWEICSG 600
GDKPLSALDS QRKLQFYEDR HQLPAPKWAE LANLINNCMD YEPDFRPSFR AIIRDLNSLF 660
TPDYELLTEN DMLPNMRIGA LGFSGAFEDR DPTQFEERHL KFLQQLGKGN FGSVEMCRYD 720
PLQDNTGEVV AVKKLQHSTE EHLRDFEREI EILKSLQHDN IVKYKGVCYS AGRRNLKLIM 780
EYLPYGSLRD YLQKHKERID HIKLLQYTSQ ICKGMEYLGT KRYIHRDLAT RNILVENENR 840
VKIGDFGLTK VLPQDKEYYK VKEPGESPIF WYAPESLTES KFSVASDVWS FGVVLYELFT 900
YIEKSKSPPA EFMRMIGNDK QGQMIVFHLI ELLKNNGRLP RPDGCPDEIY MIMTECWNNN 960
VNQRPSFRDL ALRVDQIRDN MAG 983 
Gene Ontology
 GO:0005901; C:caveola; IEA:Compara.
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
 GO:0000186; P:activation of MAPKK activity; IEA:Compara.
 GO:0031103; P:axon regeneration; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0009755; P:hormone-mediated signaling pathway; IEA:Compara.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Compara.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Compara.
 GO:0061180; P:mammary gland epithelium development; IEA:Compara.
 GO:0031959; P:mineralocorticoid receptor signaling pathway; IEA:Compara.
 GO:0030099; P:myeloid cell differentiation; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0022408; P:negative regulation of cell-cell adhesion; IEA:Compara.
 GO:0043392; P:negative regulation of DNA binding; IEA:Compara.
 GO:0045822; P:negative regulation of heart contraction; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0050867; P:positive regulation of cell activation; IEA:Compara.
 GO:0045597; P:positive regulation of cell differentiation; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0043388; P:positive regulation of DNA binding; IEA:Compara.
 GO:0050729; P:positive regulation of inflammatory response; IEA:Compara.
 GO:0032024; P:positive regulation of insulin secretion; IEA:Compara.
 GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IEA:Compara.
 GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IEA:Compara.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0033194; P:response to hydroperoxide; IEA:Compara.
 GO:0007262; P:STAT protein import into nucleus; IEA:Compara.
 GO:0042508; P:tyrosine phosphorylation of Stat1 protein; IEA:Compara.
 GO:0042503; P:tyrosine phosphorylation of Stat3 protein; IEA:Compara.
 GO:0042506; P:tyrosine phosphorylation of Stat5 protein; IEA:Compara. 
Interpro
 IPR000299; FERM_domain.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR000980; SH2.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
 IPR020693; Tyr_kinase_non-rcpt_Jak2. 
Pfam
 PF07714; Pkinase_Tyr
 PF00017; SH2 
SMART
 SM00252; SH2
 SM00219; TyrKc 
PROSITE
 PS50057; FERM_3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS50001; SH2 
PRINTS
 PR01823; JANUSKINASE.
 PR01825; JANUSKINASE2.
 PR00109; TYRKINASE.