CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022451
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myoferlin 
Protein Synonyms/Alias
 Fer-1-like protein 3 
Gene Name
 MYOF 
Gene Synonyms/Alias
 FER1L3; KIAA1207 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60QSRSLPYKLISLLNEubiquitination[1]
364VEVSFAGKKVCTNIIubiquitination[1]
485YDELNTGKGEGVAYRubiquitination[1]
505ELATFLEKTPPDKKLubiquitination[1]
525DDLLVVEKYQRRRKYubiquitination[1]
670TLPLTEGKANVTVLDubiquitination[1]
905RYPGGDWKPAEDTYTubiquitination[1]
1067TTEDGDEKSLEKQKHubiquitination[1]
1181FDNDQVGKDEFLGRSubiquitination[1]
1195SIFSPVVKLNSEMDIubiquitination[1]
1205SEMDITPKLLWHPVMubiquitination[1]
1232AELILRGKDGSNLPIubiquitination[1]
1302RVESVVIKNLKKTPNubiquitination[1]
1374EDIVPQLKASLLSAPubiquitination[1]
1394VIEMEDTKPLLASKLubiquitination[1]
1414EIVDWWSKFYASSGEubiquitination[1]
1465TFKLYRGKSDENEDPubiquitination[1]
1479PSVVGEFKGSFRIYPubiquitination[1]
1591DTFTRDEKVGETIIDubiquitination[1]
1642LQNVARFKGFPQPILubiquitination[1]
1717QPNISQGKLQMWVDVubiquitination[1]
1756RVIIWNTKDVILDEKubiquitination[1]
1763KDVILDEKSITGEEMubiquitination[1]
1776EMSDIYVKGWIPGNEubiquitination[1]
1876IPAKSPEKCRLDMIPubiquitination[1]
1886LDMIPDLKAMNPLKAubiquitination[1]
1892LKAMNPLKAKTASLFubiquitination[1]
1902TASLFEQKSMKGWWPubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). 
Sequence Annotation
 DOMAIN 1 85 C2 1.
 DOMAIN 186 281 C2 2.
 DOMAIN 345 458 C2 3.
 DOMAIN 1126 1231 C2 4.
 DOMAIN 1538 1638 C2 5.
 REGION 186 281 Necessary for interaction with EHD2.
 MOD_RES 174 174 Phosphoserine.
 MOD_RES 884 884 N6-acetyllysine.
 MOD_RES 1915 1915 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Cell membrane; Complete proteome; Cytoplasmic vesicle; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2061 AA 
Protein Sequence
MRPPKEGSGS NICCSAIFAV LQPPLVISRQ TRSGMDLQQT PTDLQLKDLT GDQSRSLPYK 60
LISLLNEKGQ DTGATIDLVI GYDPPSAPHP NDLSGPSVPG MGGDGEEDEG DEDRLDNAVR 120
GPGPKGPVGT VSEAQLARRL TKVKNSRRML SNKPQDFQIR VRVIEGRQLS GNNIRPVVKV 180
HVCGQTHRTR IKRGNNPFFD ELFFYNVNMT PSELMDEIIS IRVYNSHSLR ADCLMGEFKI 240
DVGFVYDEPG HAVMRKWLLL NDPEDTSSGS KGYMKVSMFV LGTGDEPPPE RRDRDNDSDD 300
VESNLLLPAG IALRWVTFLL KIYRAEDIPQ MDDAFSQTVK EIFGGNADKK NLVDPFVEVS 360
FAGKKVCTNI IEKNANPEWN QVVNLQIKFP SVCEKIKLTI YDWDRLTKND VVGTTYLHLS 420
KIAASGGEVE DFSSSGTGAA SYTVNTGETE VGFVPTFGPC YLNLYGSPRE YTGFPDPYDE 480
LNTGKGEGVA YRGRILVELA TFLEKTPPDK KLEPISNDDL LVVEKYQRRR KYSLSAVFHS 540
ATMLQDVGEA IQFEVSIGNY GNKFDTTCKP LASTTQYSRA VFDGNYYYYL PWAHTKPVVT 600
LTSYWEDISH RLDAVNTLLA MAERLQTNIE ALKSGIQGKI PANQLAELWL KLIDEVIEDT 660
RYTLPLTEGK ANVTVLDTQI RKLRSRSLSQ IHEAAVRMRS EATDVKSTLA EIEDWLDKLM 720
QLTEEPQNSM PDIIIWMIRG EKRLAYARIP AHQVLYSTSG ENASGKYCGK TQTIFLKYPQ 780
EKNNGPKVPV ELRVNIWLGL SAVEKKFNSF AEGTFTVFAE MYENQALMFG KWGTSGLVGR 840
HKFSDVTGKI KLKREFFLPP KGWEWEGEWI VDPERSLLTE ADAGHTEFTD EVYQNESRYP 900
GGDWKPAEDT YTDANGDKAA SPSELTCPPG WEWEDDAWSY DINRAVDEKG WEYGITIPPD 960
HKPKSWVAAE KMYHTHRRRR LVRKRKKDLT QTASSTARAM EELQDQEGWE YASLIGWKFH 1020
WKQRSSDTFR RRRWRRKMAP SETHGAAAIF KLEGALGADT TEDGDEKSLE KQKHSATTVF 1080
GANTPIVSCN FDRVYIYHLR CYVYQARNLL ALDKDSFSDP YAHICFLHRS KTTEIIHSTL 1140
NPTWDQTIIF DEVEIYGEPQ TVLQNPPKVI MELFDNDQVG KDEFLGRSIF SPVVKLNSEM 1200
DITPKLLWHP VMNGDKACGD VLVTAELILR GKDGSNLPIL PPQRAPNLYM VPQGIRPVVQ 1260
LTAIEILAWG LRNMKNFQMA SITSPSLVVE CGGERVESVV IKNLKKTPNF PSSVLFMKVF 1320
LPKEELYMPP LVIKVIDHRQ FGRKPVVGQC TIERLDRFRC DPYAGKEDIV PQLKASLLSA 1380
PPCRDIVIEM EDTKPLLASK LTEKEEEIVD WWSKFYASSG EHEKCGQYIQ KGYSKLKIYN 1440
CELENVAEFE GLTDFSDTFK LYRGKSDENE DPSVVGEFKG SFRIYPLPDD PSVPAPPRQF 1500
RELPDSVPQE CTVRIYIVRG LELQPQDNNG LCDPYIKITL GKKVIEDRDH YIPNTLNPVF 1560
GRMYELSCYL PQEKDLKISV YDYDTFTRDE KVGETIIDLE NRFLSRFGSH CGIPEEYCVS 1620
GVNTWRDQLR PTQLLQNVAR FKGFPQPILS EDGSRIRYGG RDYSLDEFEA NKILHQHLGA 1680
PEERLALHIL RTQGLVPEHV ETRTLHSTFQ PNISQGKLQM WVDVFPKSLG PPGPPFNITP 1740
RKAKKYYLRV IIWNTKDVIL DEKSITGEEM SDIYVKGWIP GNEENKQKTD VHYRSLDGEG 1800
NFNWRFVFPF DYLPAEQLCI VAKKEHFWSI DQTEFRIPPR LIIQIWDNDK FSLDDYLGFL 1860
ELDLRHTIIP AKSPEKCRLD MIPDLKAMNP LKAKTASLFE QKSMKGWWPC YAEKDGARVM 1920
AGKVEMTLEI LNEKEADERP AGKGRDEPNM NPKLDLPNRP ETSFLWFTNP CKTMKFIVWR 1980
RFKWVIIGLL FLLILLLFVA VLLYSLPNYL SMKIVKPNV 2019 
Gene Ontology
 GO:0005901; C:caveola; ISS:UniProtKB.
 GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005635; C:nuclear envelope; TAS:ProtInc.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IDA:UniProtKB.
 GO:0008015; P:blood circulation; TAS:ProtInc.
 GO:0034605; P:cellular response to heat; IEA:Compara.
 GO:0006936; P:muscle contraction; TAS:ProtInc.
 GO:0001778; P:plasma membrane repair; ISS:UniProtKB.
 GO:0030947; P:regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Compara. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR012968; FerIin-domain.
 IPR012560; Ferlin_A-domain.
 IPR012561; Ferlin_B-domain.
 IPR006614; Peroxin/Ferlin. 
Pfam
 PF00168; C2
 PF08165; FerA
 PF08150; FerB
 PF08151; FerI 
SMART
 SM00239; C2
 SM00694; DysFC
 SM00693; DysFN 
PROSITE
 PS50004; C2 
PRINTS