| Tag | Content |
|---|
| CPLM ID | CPLM-021646 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial |
Protein Synonyms/Alias | MCCase subunit beta; 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta |
Gene Name | MCCC2 |
Gene Synonyms/Alias | MCCB |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 47 | ALYQENYKQMKALVN | ubiquitination | [1] | | 151 | AYYPVTVKKQLRAQE | ubiquitination | [1] | | 382 | YEAEGIAKDGAKMVA | ubiquitination | [1] | | 449 | NVLATITKDQRAREG | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. |
Sequence Annotation | DOMAIN 55 557 Carboxyltransferase.
REGION 343 372 Acyl-CoA binding (Potential). |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Disease mutation; Ligase; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 563 AA |
Protein Sequence | MWAVLRLALR PCARASPAGP RAYHGDSVAS LGTQPDLGSA LYQENYKQMK ALVNQLHERV 60
EHIKLGGGEK ARALHISRGK LLPRERIDNL IDPGSPFLEL SQFAGYQLYD NEEVPGGGII 120
TGIGRVSGVE CMIIANDATV KGGAYYPVTV KKQLRAQEIA MQNRLPCIYL VDSGGAYLPR 180
QADVFPDRDH FGRTFYNQAI MSSKNIAQVK AATGEEVSAE DLGGADLHCR KSGVSDHWAL 240
DDHHALHLTR KVVRNLNYQK KLDVTIEPSE EPLFPADELY GIVGANLKRS FDVREVIARI 300
VDGSRFTEFK AFYGDTLVTG FARIFGYPVG IVGNNGVLFS ESAKKGTHFV QLCCQRNIPL 360
LFLQNITGFM VGREYEAEGI AKDGAKMVAA VACAQVPKIT LIIGGSYGAG NYGMCGRAYS 420
PRFLYIWPNA RISVMGGEQA ANVLATITKD QRAREGKQFS SADEAALKEP IIKKFEEEGN 480
PYYSSARVWD DGIIDPADTR LVLGLSFSAA LNAPIEKTDF GIFRM 525 |
Gene Ontology | GO:0005743; C:mitochondrial inner membrane; TAS:Reactome. GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004485; F:methylcrotonoyl-CoA carboxylase activity; IDA:UniProtKB. GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome. GO:0015936; P:coenzyme A metabolic process; IEA:Compara. GO:0006552; P:leucine catabolic process; TAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |