UniProt Accession

 IMPA2_HUMAN; O14732; B0YJ29; Q9UJT3 

Genbank Protein ID

 AF014398; AF157102; AF157096; AF157097; AF157098; AF157099; AF157100; AF157101; AF200432; BT007061; EF444990; CH471113; BC017176 

Genbank Nucleotide ID

 AAB70915.1; AAD40683.1; AAD40683.1; AAD40683.1; AAD40683.1; AAD40683.1; AAD40683.1; AAD40683.1; AAF07824.1; AAP35710.1; ACA06007.1; EAX01559.1; AAH17176.1 

Protein Name

 Inositol monophosphatase 2 

Protein Synonyms/Alias

 IMP 2; IMPase 2; Inositol-1(or 4)-monophosphatase 2; Myo-inositol monophosphatase A2 

Gene Name

 IMPA2 

Gene Synonyms/Alias

 IMP.18P 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
184	KRDPATLKLFLSNME	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. 

Sequence Annotation

 REGION 103 106 Substrate binding.
 REGION 205 207 Substrate binding.
 METAL 81 81 Magnesium 1 (By similarity).
 METAL 101 101 Magnesium 1 (By similarity).
 METAL 101 101 Magnesium 2 (By similarity).
 METAL 103 103 Magnesium 1; via carbonyl oxygen (By
 METAL 104 104 Magnesium 2 (By similarity).
 METAL 231 231 Magnesium 2 (By similarity).
 BINDING 81 81 Substrate.
 BINDING 224 224 Substrate.
 BINDING 231 231 Substrate (By similarity).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Hydrolase; Magnesium; Metal-binding; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0008934; F:inositol monophosphate 1-phosphatase activity; IDA:MGI.
 GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:EC.
 GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR020583; Inositol_monoP_metal-BS.
 IPR020552; Inositol_monoPase_Li-sen.
 IPR000760; Inositol_monophosphatase.
 IPR020550; Inositol_monophosphatase_CS. 

Pfam

 PF00459; Inositol_P 

SMART

  

PROSITE

 PS00629; IMP_1
 PS00630; IMP_2 

PRINTS

 PR00377; IMPHPHTASES.
 PR00378; LIIMPHPHTASE.