UniProt Accession

 COX7B_HUMAN; P24311; B2R4M3; Q6ICR1 

Genbank Protein ID

 Z14244; BT009767; CR450332; CR542124; AK311879; AL356235; CH471104; BC018386 

Genbank Nucleotide ID

 CAA78613.1; AAP88769.1; CAG29328.1; CAG46921.1; BAG34820.1; CAH70525.1; EAW98607.1; AAH18386.1 

Protein Name

 Cytochrome c oxidase subunit 7B, mitochondrial 

Protein Synonyms/Alias

 Cytochrome c oxidase polypeptide VIIb 

Gene Name

 COX7B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
75	PVGRVTPKEWRNQ**	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates. 

Sequence Annotation

  

Keyword

 Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 80 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0005746; C:mitochondrial respiratory chain; IEA:InterPro.
 GO:0004129; F:cytochrome-c oxidase activity; TAS:ProtInc.
 GO:0007417; P:central nervous system development; IMP:UniProtKB.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR008433; Cyt_c_oxidase_suVIIB.
 IPR023272; Cyt_c_oxidase_suVIIB_dom. 

Pfam

 PF05392; COX7B 

SMART

  

PROSITE

  

PRINTS