| Tag | Content |
|---|
| CPLM ID | CPLM-001788 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PTS system mannitol-specific EIICBA component |
Protein Synonyms/Alias | EIICBA-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific EIIA component |
Gene Name | mtlA |
Gene Synonyms/Alias | b3599; JW3573 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 483 | EKVKDSLKDSFDDSS | acetylation | [1] | | 495 | DSSANLFKLGAENIF | acetylation | [1] | | 523 | FAGEQLVKGGYVEPE | acetylation | [1] | | 540 | QAMLDREKLTPTYLG | acetylation | [1] | | 560 | PHGTVEAKDRVLKTG | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport. |
Sequence Annotation | DOMAIN 12 341 PTS EIIC type-2.
DOMAIN 378 473 PTS EIIB type-2.
DOMAIN 494 636 PTS EIIA type-2.
ACT_SITE 384 384 Phosphocysteine intermediate; for EIIB
ACT_SITE 554 554 Tele-phosphohistidine intermediate; for |
Keyword | 3D-structure; Cell inner membrane; Cell membrane; Complete proteome; Kinase; Membrane; Phosphotransferase system; Reference proteome; Sugar transport; Transferase; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 637 AA |
Protein Sequence | MSSDIKIKVQ SFGRFLSNMV MPNIGAFIAW GIITALFIPT GWLPNETLAK LVGPMITYLL 60
PLLIGYTGGK LVGGERGGVV GAITTMGVIV GADMPMFLGS MIAGPLGGWC IKHFDRWVDG 120
KIKSGFEMLV NNFSAGIIGM ILAILAFLGI GPIVEALSKM LAAGVNFMVV HDMLPLASIF 180
VEPAKILFLN NAINHGIFSP LGIQQSHELG KSIFFLIEAN PGPGMGVLLA YMFFGRGSAK 240
QSAGGAAIIH FLGGIHEIYF PYVLMNPRLI LAVILGGMTG VFTLTILGGG LVSPASPGSI 300
LAVLAMTPKG AYFANIAGVC AAMAVSFVVS AILLKTSKVK EEDDIEAATR RMQDMKAESK 360
GASPLSAGDV TNDLSHVRKI IVACDAGMGS SAMGAGVLRK KIQDAGLSQI SVTNSAINNL 420
PPDVDLVITH RDLTERAMRQ VPQAQHISLT NFLDSGLYTS LTERLVAAQR HTANEEKVKD 480
SLKDSFDDSS ANLFKLGAEN IFLGRKAATK EEAIRFAGEQ LVKGGYVEPE YVQAMLDREK 540
LTPTYLGESI AVPHGTVEAK DRVLKTGVVF CQYPEGVRFG EEEDDIARLV IGIAARNNEH 600
IQVITSLTNA LDDESVIERL AHTTSVDEVL ELLAGRK 637 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0016301; F:kinase activity; IEA:UniProtKB-KW. GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:EC. GO:0005351; F:sugar:hydrogen symporter activity; IEA:InterPro. GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |