UniProt Accession

 LRC8C_HUMAN; Q8TDW0; B3KXS9; Q29RV6; Q9H075 

Genbank Protein ID

 AB081509; AK127881; AC093423; BC113973; AL136919 

Genbank Nucleotide ID

 BAB86303.1; BAG54591.1; AAI13974.1; CAB66853.2 

Protein Name

 Leucine-rich repeat-containing protein 8C 

Protein Synonyms/Alias

 Factor for adipocyte differentiation 158 

Gene Name

 LRRC8C 

Gene Synonyms/Alias

 AD158; FAD158 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
214	LVNSQSLKSIPEKFV	ubiquitination	[1]
219	SLKSIPEKFVVDKST	ubiquitination	[2]
401	EVSENKLKQLNLNNE	ubiquitination	[2]
499	NLKVLSVKFDDMREL	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 May play a role in adipogenesis (By similarity). 

Sequence Annotation

 REPEAT 397 419 LRR 1.
 REPEAT 420 443 LRR 2.
 REPEAT 446 465 LRR 3.
 REPEAT 468 490 LRR 4.
 REPEAT 492 513 LRR 5.
 REPEAT 515 536 LRR 6.
 REPEAT 543 563 LRR 7.
 REPEAT 566 586 LRR 8.
 REPEAT 590 611 LRR 9.
 REPEAT 613 634 LRR 10.
 REPEAT 638 659 LRR 11.
 REPEAT 661 682 LRR 12.
 REPEAT 684 705 LRR 13.
 REPEAT 707 728 LRR 14.
 REPEAT 730 751 LRR 15.
 REPEAT 753 774 LRR 16.
 REPEAT 776 799 LRR 17.
 MOD_RES 198 198 Phosphothreonine (By similarity).
 MOD_RES 212 212 Phosphoserine (By similarity).
 MOD_RES 215 215 Phosphoserine (By similarity).
 CARBOHYD 70 70 N-linked (GlcNAc...) (Potential).
 CARBOHYD 194 194 N-linked (GlcNAc...) (Potential).
 CARBOHYD 305 305 N-linked (GlcNAc...) (Potential).
 CARBOHYD 552 552 N-linked (GlcNAc...) (Potential).
 CARBOHYD 590 590 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Endoplasmic reticulum; Glycoprotein; Leucine-rich repeat; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 803 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR021040; LRR_protein-8_N. 

Pfam

 PF12534; DUF3733
 PF00560; LRR_1 

SMART

 SM00369; LRR_TYP 

PROSITE

 PS51450; LRR 

PRINTS