UniProt Accession

 VPS28_YEAST; Q02767; D6W3V0; E9P8X2; P87328 

Genbank Protein ID

 U50630; U39205; AY692790; BK006949 

Genbank Nucleotide ID

 AAB40936.1; AAB68300.1; AAT92809.1; DAA11366.1 

Protein Name

 Vacuolar protein sorting-associated protein 28 

Protein Synonyms/Alias

 ESCRT-I complex subunit VPS28 

Gene Name

 VPS28 

Gene Synonyms/Alias

 VPT28; YPL065W; LPE5W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
59	HVEKAYLKDSIDDTQ	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for normal endocytic and biosynthetic traffic to the yeast vacuole. 

Sequence Annotation

 DOMAIN 11 125 VPS28 N-terminal.
 DOMAIN 148 242 VPS28 C-terminal.
 REGION 148 242 Interaction with VSP36 and VPS20.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 242 AA 

Protein Sequence

Gene Ontology

 GO:0000813; C:ESCRT I complex; IDA:SGD.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0032403; F:protein complex binding; IDA:SGD.
 GO:0006612; P:protein targeting to membrane; IMP:SGD.
 GO:0006623; P:protein targeting to vacuole; IMP:SGD.
 GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IC:SGD. 

Interpro

 IPR007143; VPS28.
 IPR017899; VPS28_C.
 IPR017898; VPS28_N. 

Pfam

 PF03997; VPS28 

SMART

  

PROSITE

 PS51310; VPS28_C
 PS51313; VPS28_N 

PRINTS