| Tag | Content |
|---|
| CPLM ID | CPLM-015612 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras-associated and pleckstrin homology domains-containing protein 1 |
Protein Synonyms/Alias | RAPH1; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein; Lamellipodin; Proline-rich EVH1 ligand 2; PREL-2; Protein RMO1 |
Gene Name | RAPH1 |
Gene Synonyms/Alias | ALS2CR18; ALS2CR9; KIAA1681; LPD; PREL2; RMO1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 535 | SLSSSSIKSGSSSSS | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
Sequence Annotation | DOMAIN 269 355 Ras-associating.
DOMAIN 396 505 PH.
MOD_RES 1 1 N-acetylmethionine.
MOD_RES 5 5 Phosphoserine.
MOD_RES 17 17 Phosphoserine.
MOD_RES 54 54 Phosphoserine.
MOD_RES 426 426 Phosphotyrosine; by ABL1.
MOD_RES 456 456 Phosphotyrosine; by ABL1.
MOD_RES 610 610 Phosphoserine.
MOD_RES 827 827 Phosphoserine.
MOD_RES 830 830 Phosphothreonine.
MOD_RES 853 853 Phosphoserine.
MOD_RES 894 894 Phosphoserine.
MOD_RES 965 965 Phosphoserine.
MOD_RES 974 974 Phosphothreonine.
MOD_RES 1226 1226 Phosphotyrosine; by ABL1. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1250 AA |
Protein Sequence | MEQLSDEEID HGAEEDSDKE DQDLDKMFGA WLGELDKLTQ SLDSDKPMEP VKRSPLRQET 60
NMANFSYRFS IYNLNEALNQ GETVDLDALM ADLCSIEQEL SSIGSGNSKR QITETKATQK 120
LPVSRHTLKH GTLKGLSSSS NRIAKPSHAS YSLDDVTAQL EQASLSMDEA AQQSVLEDTK 180
PLVTNQHRRT ASAGTVSDAE VHSISNSSHS SITSAASSMD SLDIDKVTRP QELDLTHQGQ 240
PITEEEQAAK LKAEKIRVAL EKIKEAQVKK LVIRVHMSDD SSKTMMVDER QTVRQVLDNL 300
MDKSHCGYSL DWSLVETVSE LQMERIFEDH ENLVENLLNW TRDSQNKLIF MERIEKYALF 360
KNPQNYLLGK KETAEMADRN KEVLLEECFC GSSVTVPEIE GVLWLKDDGK KSWKKRYFLL 420
RASGIYYVPK GKAKVSRDLV CFLQLDHVNV YYGQDYRNKY KAPTDYCLVL KHPQIQKKSQ 480
YIKYLCCDDV RTLHQWVNGI RIAKYGKQLY MNYQEALKRT ESAYDWTSLS SSSIKSGSSS 540
SSIPESQSNH SNQSDSGVSD TQPAGHVRSQ SIVSSVFSEA WKRGTQLEES SKARMESMNR 600
PYTSLVPPLS PQPKIVTPYT ASQPSPPLPP PPPPPPPPPP PPPPPPPPLP SQSAPSAGSA 660
APMFVKYSTI TRLQNASQHS GALFKPPTPP VMQSQSVKPQ ILVPPNGVVP PPPPPPPPPT 720
PGSAMAQLKP APCAPSLPQF SAPPPPLKIH QVQHITQVAP PTPPPPPPIP APLPPQAPPK 780
PLVTIPAPTS TKTVAPVVTQ AAPPTPTPPV PPAKKQPAFP ASYIPPSPPT PPVPVPPPTL 840
PKQQSFCAKP PPSPLSPVPS VVKQIASQFP PPPTPPAMES QPLKPVPANV APQSPPAVKA 900
KPKWQPSSIP VPSPDFPPPP PESSLVFPPP PPSPVPAPPP PPPPTASPTP DKSGSPGKKT 960
SKTSSPGGKK PPPTPQRNSS IKSSSGAEHP EPKRPSVDSL VSKFTPPAES GSPSKETLPP 1020
PAAPPKPGKL NLSGVNLPGV LQQGCVSAKA PVLSGRGKDS VVEFPSPPSD SDFPPPPPET 1080
ELPLPPIEIP AVFSGNTSPK VAVVNPQPQQ WSKMSVKKAP PPTRPKRNDS TRLTQAEISE 1140
QPTMATVVPQ VPTSPKSSLS VQPGFLADLN RTLQRKSITR HGSLSSRMSR AEPTATMDDM 1200
ALPPPPPELL SDQQKAGYGG SHISGYATLR RGPPPAPPKR DQNTKLSRDW 1250 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |