CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015838
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tripartite motif-containing protein 46 
Protein Synonyms/Alias
 Gene Y protein; GeneY; Tripartite, fibronectin type-III and C-terminal SPRY motif protein 
Gene Name
 Trim46 
Gene Synonyms/Alias
 Trific 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
550RERLAISKDQRAVRSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 DOMAIN 370 427 COS.
 DOMAIN 430 525 Fibronectin type-III.
 DOMAIN 526 747 B30.2/SPRY.
 ZN_FING 33 73 RING-type 1; degenerate.
 ZN_FING 172 231 RING-type 2; degenerate.
 ZN_FING 222 263 B box-type.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 759 AA 
Protein Sequence
MAEGEDMQTF TSIMDALVRI STSMKNMEKE LLCPVCQEMY KQPLVLPCTH NVCQACAREV 60
LGQQGYIGHG GDPSSEPTSP ASTPSTRSPR LSRRTLPKPD RLDRLLKSGF GTYPGRKRGA 120
LHPQTILFPC PACQGDVELG ERGLSGLFRN LTLERVVERY RQSVSVGGAI LCQLCKPPPL 180
EATKGCTECR ATFCNECFKL FHPWGTQKAQ HEPTLPTLSF RPKGLMCPDH KEEVTHYCKT 240
CQRLVCQLCR VRRTHSGHKI TPVLSAYQAL KDKLTKSLAY ILGNQDTVQT QICELEETIR 300
HTEVSGQQAK EEVSQLVRGL GAVLEEKRAS LLQAIEECQQ ERLSRLSAQI HEHQSLLDGS 360
GLVGYAQEVL KETDQPCFVQ AAKQLHNRIA RATEALQTFR PAASSSFRHC QLDVGREMKL 420
LTELSFLRVP EAPVIDTQRT FAYDQIFLCW RLPPHSPPAW HYTVEFRRTD VPAQPGPTRW 480
QRREEVRGTS ALLENPDTGS VYVLRVRGCN KAGYGEYSED VHLHTPPAPV LHFFLDGRWG 540
ASRERLAISK DQRAVRSIPG LPLLLAAERL LTGCHLSVDV VLGDVAVTQG RSYWACAVDP 600
ASYLVKVGVG LESKLQESFQ GAPDVISPRY DPDSGHDSGA EDAAVEALPP FAFLTIGMGK 660
ILLGSGASSN AGLTGRDGPT ASCTVPLPPR LGICLDYERG RVSFLDAVSF RGLLECPLDC 720
SGPVCPAFCF IGGGAVQLQE PVGTKPERKV TIGGFAKLD 759 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR017903; COS_domain.
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR000315; Znf_B-box.
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00643; zf-B_box
 PF00097; zf-C3HC4 
SMART
 SM00336; BBOX
 SM00060; FN3
 SM00184; RING 
PROSITE
 PS50188; B302_SPRY
 PS51262; COS
 PS50853; FN3
 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS