CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010964
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptic vesicle glycoprotein 2A 
Protein Synonyms/Alias
 Synaptic vesicle protein 2; Synaptic vesicle protein 2A 
Gene Name
 Sv2a 
Gene Synonyms/Alias
 Sv2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
143RGEAQRRKDREELAQubiquitination[1]
515GGQYFNDKFIGLRLKacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. 
Sequence Annotation
 REGION 1 57 Interaction with SYT1.
 REGION 543 580 BOTA-binding (By similarity).
 MOD_RES 65 65 Phosphotyrosine (By similarity).
 MOD_RES 66 66 Phosphotyrosine (By similarity).
 MOD_RES 80 80 Phosphoserine (By similarity).
 MOD_RES 81 81 Phosphoserine (By similarity).
 MOD_RES 84 84 Phosphothreonine (By similarity).
 MOD_RES 127 127 Phosphoserine (By similarity).
 MOD_RES 480 480 Phosphotyrosine (By similarity).
 CARBOHYD 498 498 N-linked (GlcNAc...) (Potential).
 CARBOHYD 548 548 N-linked (GlcNAc...) (Potential).
 CARBOHYD 573 573 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell junction; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Glycoprotein; Membrane; Neurotransmitter transport; Phosphoprotein; Receptor; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 742 AA 
Protein Sequence
MEEGFRDRAA FIRGAKDIAK EVKKHAAKKV VKGLDRVQDE YSRRSYSRFE EEEDDDDFPA 60
PADGYYRGEG AQDEEEGGAS SDATEGHDED DEIYEGEYQG IPRAESGGKG ERMADGAPLA 120
GVRGGLSDGE GPPGGRGEAQ RRKDREELAQ QYETILRECG HGRFQWTLYF VLGLALMADG 180
VEVFVVGFVL PSAEKDMCLS DSNKGMLGLI VYLGMMVGAF LWGGLADRLG RRQCLLISLS 240
VNSVFAFFSS FVQGYGTFLF CRLLSGVGIG GSIPIVFSYF SEFLAQEKRG EHLSWLCMFW 300
MIGGVYAAAM AWAIIPHYGW SFQMGSAYQF HSWRVFVLVC AFPSVFAIGA LTTQPESPRF 360
FLENGKHDEA WMVLKQVHDT NMRAKGHPER VFSVTHIKTI HQEDELIEIQ SDTGTWYQRW 420
GVRALSLGGQ VWGNFLSCFS PEYRRITLMM MGVWFTMSFS YYGLTVWFPD MIRHLQAVDY 480
AARTKVFPGE RVEHVTFNFT LENQIHRGGQ YFNDKFIGLR LKSVSFEDSL FEECYFEDVT 540
SSNTFFRNCT FINTVFYNTD LFEYKFVNSR LVNSTFLHNK EGCPLDVTGT GEGAYMVYFV 600
SFLGTLAVLP GNIVSALLMD KIGRLRMLAG SSVLSCVSCF FLSFGNSESA MIALLCLFGG 660
VSIASWNALD VLTVELYPSD KRTTAFGFLN ALCKLAAVLG ISIFTSFVGI TKAAPILFAS 720
AALALGSSLA LKLPETRGQV LQ 742 
Gene Ontology
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016021; C:integral to membrane; IDA:RGD.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0048786; C:presynaptic active zone; IEA:Compara.
 GO:0030672; C:synaptic vesicle membrane; IDA:RGD.
 GO:0004872; F:receptor activity; IEA:Compara.
 GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
 GO:0005215; F:transporter activity; TAS:RGD.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0006836; P:neurotransmitter transport; TAS:RGD. 
Interpro
 IPR001646; 5peptide_repeat.
 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR005828; Sub_transporter.
 IPR005829; Sugar_transporter_CS.
 IPR022308; SV2. 
Pfam
 PF07690; MFS_1
 PF13599; Pentapeptide_4
 PF00083; Sugar_tr 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS