CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040436
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HRAS1 
Protein Synonyms/Alias
 Harvey rat sarcoma virus oncogene 1, isoform CRA_b 
Gene Name
 Hras1 
Gene Synonyms/Alias
 mCG_22575 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
101HQYREQIKRVKDSDDubiquitination[1]
147PYIETSAKTRQGVEDubiquitination[1]
170IRQHKLRKLNPPDESubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 GTP-binding; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 189 AA 
Protein Sequence
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 60
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI KRVKDSDDVP MVLVGNKCDL 120
AARTVESRQA QDLARSYGIP YIETSAKTRQ GVEDAFYTLV REIRQHKLRK LNPPDESGPG 180
CMSCKCVLS 189 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005525; F:GTP binding; IDA:MGI.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0007569; P:cell aging; IDA:MGI.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0008283; P:cell proliferation; IPI:MGI.
 GO:0090398; P:cellular senescence; IEA:Compara.
 GO:0006897; P:endocytosis; IDA:MGI.
 GO:0006917; P:induction of apoptosis; IGI:MGI.
 GO:0097193; P:intrinsic apoptotic signaling pathway; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IDA:MGI.
 GO:0034259; P:negative regulation of Rho GTPase activity; IEA:Compara.
 GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Compara.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IDA:MGI.
 GO:0046330; P:positive regulation of JNK cascade; IEA:Compara.
 GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
 GO:2000630; P:positive regulation of miRNA metabolic process; IEA:Compara.
 GO:0032855; P:positive regulation of Rac GTPase activity; IEA:Compara.
 GO:0046579; P:positive regulation of Ras protein signal transduction; ISO:MGI.
 GO:1900029; P:positive regulation of ruffle assembly; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0090303; P:positive regulation of wound healing; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0007265; P:Ras protein signal transduction; TAS:MGI.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
 GO:0035176; P:social behavior; IEA:Compara. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 
Pfam
 PF00071; Ras 
SMART
 SM00173; RAS 
PROSITE
 PS51421; RAS 
PRINTS
 PR00449; RASTRNSFRMNG.