UniProt Accession

 A4QPA9_HUMAN; A4QPA9 

Genbank Protein ID

 BC137459; BC139729; AK291500; CH471082 

Genbank Nucleotide ID

 AAI37460.1; AAI39730.1; BAF84189.1; EAW77765.1 

Protein Name

 Mitogen-activated protein kinase kinase 1 

Protein Synonyms/Alias

 Mitogen-activated protein kinase kinase 1, isoform CRA_a; cDNA FLJ76051, highly similar to Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA 

Gene Name

 MAP2K1 

Gene Synonyms/Alias

 hCG_24510 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
104	KLIHLEIKPAIRNQI	ubiquitination	[1, 2]
175	KVSIAVIKGLTYLRE	ubiquitination	[2]
353	PAERADLKQLMVHAF	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Kinase; Nucleotide-binding; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0032839; C:dendrite cytoplasm; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0043204; C:perikaryon; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004708; F:MAP kinase kinase activity; IEA:Compara.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0004728; F:receptor signaling protein tyrosine phosphatase activity; IEA:Compara.
 GO:0048870; P:cell motility; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0048313; P:Golgi inheritance; IEA:Compara.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0060711; P:labyrinthine layer development; IEA:Compara.
 GO:0032402; P:melanosome transport; IEA:Compara.
 GO:0007067; P:mitosis; IEA:Compara.
 GO:0034111; P:negative regulation of homotypic cell-cell adhesion; IEA:Compara.
 GO:0048812; P:neuron projection morphogenesis; IEA:Compara.
 GO:0060674; P:placenta blood vessel development; IEA:Compara.
 GO:0045597; P:positive regulation of cell differentiation; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0032320; P:positive regulation of Ras GTPase activity; IEA:Compara.
 GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Compara.
 GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0003056; P:regulation of vascular smooth muscle contraction; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0047496; P:vesicle transport along microtubule; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS