CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026254
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pumilio homolog 1 
Protein Synonyms/Alias
 Pumilio homolog 1 (Drosophila), isoform CRA_c 
Gene Name
 PUM1 
Gene Synonyms/Alias
 hCG_19946 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
306GDKLGDLKEEGDVMDubiquitination[1]
754TGSSDLYKRTSSSLTubiquitination[1, 2]
830AAPGAEAKYRSASSAubiquitination[1, 2]
950EFGSLEQKLALAERIubiquitination[1]
976YGCRVIQKALEFIPSubiquitination[1, 3]
1122FASNVVEKCVTHASRubiquitination[1]
1165YANYVVQKMIDVAEPubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1224 AA 
Protein Sequence
MPLPPPGPGP EPIPGCTAPT QSPVGRHVVG VKGVGGMSVA CVLKRKAVLW QDSFSPHLKH 60
HPQEPANPNM PVVLTSGTGS QAQPQPAANQ ALAAGTHSSP VPGSIGVAGR SQDDAMVDYF 120
FQRQHGEQLG GGGSGGGGYN NSKHRWPTGD NIHAEHQVRS MDELNHDFQA LALEGRAMGE 180
QLLPGKKFWE TDESSKDGPK GIFLGDQWRD SAWGTSDHSV SQPIMVQRRP GQSFHVNSEV 240
NSVLSPRSES GGLGVSMVEY VLSSSPGDSC LRKGGFGPRD ADSDENDKGE KKNKGTFDGD 300
KLGDLKEEGD VMDKTNGLPV QNGIDADVKD FSRTPGNCQN SANEVDLLGP NQNGSEGLAQ 360
LTSTNGAKPV EDFSNMESQS VPLDPMEHVG MEPLQFDYSG TQVPVDSAAA TVGLFDYNSQ 420
QQLFQRPNAL AVQQLTAAQQ QQYALAAAHQ PHIGLAPAAF VPNPYIISAA PPGTDPYTAG 480
LAAAATLGPA VVPHQYYGVT PWGVYPASLF QQQAAAAAAA TNSANQQTTP QAQQGQQQVL 540
RGGASQRPLT PNQNQQGQQT DPLVAAAAVN SALAFGQGLA AGMPGYPVLA PAAYYDQTGA 600
LVVNAGARNG LGAPVRLVAP APVIISSSAA QAAVAAAAAS ANGAAGGLAG TTNGPFRPLG 660
TQQPQPQPQQ QPNNNLASSS FYGNNSLNSN SQSSSLFSQG SAQPANTSLG FGSSSSLGAT 720
LGSALGGFGT AVANSNTGSG SRRDSLTGSS DLYKRTSSSL TPIGHSFYNG LSFSSSPGPV 780
GMPLPSQGPG HSQTPPPSLS SHGSSSSLNL GGLTNGSGRY ISAAPGAEAK YRSASSASSL 840
FSPSSTLFSS SRLRYGMSDV MPSGRSRLLE DFRNNRYPNL QLREIAGHIM EFSQDQHGSR 900
FIQLKLERAT PAERQLVFNE ILQAAYQLMV DVFGNYVIQK FFEFGSLEQK LALAERIRGH 960
VLSLALQMYG CRVIQKALEF IPSDQQVINE MVRELDGHVL KCVKDQNGNH VVQKCIECVQ 1020
PQSLQFIIDA FKGQVFALST HPYGCRVIQR ILEHCLPDQT LPILEELHQH TEQLVQDQYG 1080
NYVIQHVLEH GRPEDKSKIV AEIRGNVLVL SQHKFASNVV EKCVTHASRT ERAVLIDEVC 1140
TMNDGPHSAL YTMMKDQYAN YVVQKMIDVA EPGQRKIVMH KIRPHIATLR KYTYGKHILA 1200
KLEKYYMKNG VDLGPICGPP NGII 1224 
Gene Ontology
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR001313; Pumilio_RNA-bd_rpt. 
Pfam
 PF00806; PUF 
SMART
 SM00025; Pumilio 
PROSITE
 PS50302; PUM
 PS50303; PUM_HD 
PRINTS