CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006474
UniProt Accession
Genbank Protein ID
 S49542 
Genbank Nucleotide ID
Protein Name
 5-hydroxytryptamine receptor 2A 
Protein Synonyms/Alias
 5-HT-2; 5-HT-2A; Serotonin receptor 2A 
Gene Name
 Htr2a 
Gene Synonyms/Alias
 Htr2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
277SDLSTRAKLSSFSFLubiquitination[1]
293QSSLSSEKLFQRSIHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. 
Sequence Annotation
 MOTIF 469 471 PDZ-binding.
 CARBOHYD 8 8 N-linked (GlcNAc...) (Potential).
 CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
 CARBOHYD 44 44 N-linked (GlcNAc...) (Potential).
 CARBOHYD 51 51 N-linked (GlcNAc...) (Potential).
 CARBOHYD 54 54 N-linked (GlcNAc...) (Potential).
 DISULFID 148 227 By similarity.  
Keyword
 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 471 AA 
Protein Sequence
MEILCEDNIS LSSIPNSLMQ LGDDSRLYPN DFNSRDANTS EASNWTIDAE NRTNLSCEGY 60
LPPTCLSILH LQEKNWSALL TTVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD 120
MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP 180
IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF 240
VAFFIPLTIM VITYFLTIKS LQKEATLCVS DLSTRAKLSS FSFLPQSSLS SEKLFQRSIH 300
REPGSYAGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNENVIGA 360
LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENRKPLQLIL VNTIPTLAYK 420
SSQLQVGQKK NSQEDAEPTA NDCSMVTLGN QHSEEMCTDN IETVNEKVSC V 471 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043198; C:dendritic shaft; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0071886; F:1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; IEA:Compara.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:Compara.
 GO:0051378; F:serotonin binding; ISO:MGI.
 GO:0004993; F:serotonin receptor activity; ISO:MGI.
 GO:0007568; P:aging; IEA:Compara.
 GO:0008219; P:cell death; IEA:Compara.
 GO:0070371; P:ERK1 and ERK2 cascade; IEA:Compara.
 GO:0007613; P:memory; IEA:Compara.
 GO:0043267; P:negative regulation of potassium ion transport; IEA:Compara.
 GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IEA:Compara.
 GO:0014065; P:phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:Compara.
 GO:0007208; P:phospholipase C-activating serotonin receptor signaling pathway; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:1900482; P:positive regulation of diacylglycerol biosynthetic process; IEA:InterPro.
 GO:0032962; P:positive regulation of inositol trisphosphate biosynthetic process; IEA:InterPro.
 GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
 GO:0045907; P:positive regulation of vasoconstriction; IEA:Compara.
 GO:0050795; P:regulation of behavior; IEA:InterPro.
 GO:0050880; P:regulation of blood vessel size; IEA:InterPro.
 GO:0014059; P:regulation of dopamine secretion; IEA:Compara.
 GO:0046883; P:regulation of hormone secretion; IEA:InterPro.
 GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0006950; P:response to stress; IEA:Compara.
 GO:0019233; P:sensory perception of pain; IEA:Compara.
 GO:0030431; P:sleep; IEA:Compara.
 GO:0006939; P:smooth muscle contraction; IEA:InterPro.
 GO:0001659; P:temperature homeostasis; IEA:Compara. 
Interpro
 IPR000455; 5HT2A_rcpt.
 IPR002231; 5HT_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00516; 5HT2ARECEPTR.
 PR01101; 5HTRECEPTOR.
 PR00237; GPCRRHODOPSN.