UniProt Accession

 H33C_DICDI; Q55BP0 

Genbank Protein ID

 AAFI02000005 

Genbank Nucleotide ID

 EAL72896.1 

Protein Name

 Histone H3.3 type c 

Protein Synonyms/Alias

 Histone 3, variant 3 type c 

Gene Name

 H3c 

Gene Synonyms/Alias

 DDB_G0271092 

Created Date

 July 27, 2013 

Organism

 Dictyostelium discoideum (Slime mold) 

NCBI Taxa ID

 44689 

Lysine Modification

Position	Peptide	Type	References
5	***MARTKQTARKST	methylation	[1]
10	RTKQTARKSTGAKVP	methylation	[1]

Reference

 [1] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 5 5 N6,N6,N6-trimethyllysine; by set1;
 MOD_RES 5 5 N6,N6-dimethyllysine; by set1; alternate.
 MOD_RES 5 5 N6-acetyllysine; alternate (By
 MOD_RES 5 5 N6-methyllysine; by set1; alternate.
 MOD_RES 10 10 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 10 10 N6,N6-dimethyllysine; alternate.
 MOD_RES 10 10 N6-acetyllysine; alternate (By
 MOD_RES 10 10 N6-methyllysine; alternate (By
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 15 15 N6-acetyllysine (By similarity).
 MOD_RES 19 19 N6-acetyllysine; alternate (By
 MOD_RES 19 19 N6-methyllysine; alternate (By
 MOD_RES 24 24 N6-acetyllysine; alternate (By
 MOD_RES 24 24 N6-methyllysine; alternate (By
 MOD_RES 37 37 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 37 37 N6,N6-dimethyllysine; alternate (By
 MOD_RES 37 37 N6-acetyllysine; alternate (By
 MOD_RES 37 37 N6-methyllysine; alternate (By
 MOD_RES 57 57 N6-acetyllysine (By similarity).
 MOD_RES 80 80 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 80 80 N6,N6-dimethyllysine; alternate.
 MOD_RES 80 80 N6-methyllysine; alternate (By  

Keyword

 Acetylation; Chromosome; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; DNA-binding; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 136 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:InterPro.
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0000160; P:phosphorelay signal transduction system; IEA:GOC.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000164; Histone_H3.
 IPR003661; Sig_transdc_His_kin_sub1_dim/P. 

Pfam

 PF00125; Histone 

SMART

 SM00428; H3
 SM00388; HisKA 

PROSITE

 PS00322; HISTONE_H3_1
 PS00959; HISTONE_H3_2 

PRINTS

 PR00622; HISTONEH3.