CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042987
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine palmitoyltransferase 2 
Protein Synonyms/Alias
  
Gene Name
 SPTLC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98HDYNWSFKYTGNIIKubiquitination[1]
131SCQEAAAKVLEEYGAubiquitination[2]
152QEIGNLDKHEELEELubiquitination[2]
230QSLEKLLKDAIVYGQubiquitination[2]
328SGGYIGGKKELIDYLubiquitination[2]
329GGYIGGKKELIDYLRubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 407 AA 
Protein Sequence
XETPMLVAVL TYVGYGVLTL FGYLRDFLRY WRIEKCHHAT EREEQKDFVS LYQDFENFYT 60
RNLYMRIRDN WNRPICSVPG ARVDIMERQS HDYNWSFKYT GNIIKGVINM GSYNYLGFAR 120
NTGSCQEAAA KVLEEYGAGV CSTRQEIGNL DKHEELEELV ARFLGVEAAM AYGMGFATNS 180
MNIPALVGKG CLILSDELNH ASLVLGARLS GATIRIFKHN NMQSLEKLLK DAIVYGQPRT 240
RRPWKKILIL VEGIYSMEGS IVRLPEVIAL KKKYKAYLYL DEAHSIGALG PTGRGVVEYF 300
GLDPEDVDVM MGTFTKSFGA SGGYIGGKKE LIDYLRTHSH SAVYATSLSP PVVEQIITSM 360
KCIMGQDGTS LGNGITIHEV VQTRNTYHRF SPLSPVFSHQ CLWIMLP 407 
Gene Ontology
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0016740; F:transferase activity; IEA:InterPro.
 GO:0009058; P:biosynthetic process; IEA:InterPro. 
Interpro
 IPR001917; Aminotrans_II_pyridoxalP_BS.
 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1. 
Pfam
 PF00155; Aminotran_1_2 
SMART
  
PROSITE
 PS00599; AA_TRANSFER_CLASS_2 
PRINTS