UniProt Accession

 ABI1_MOUSE; Q8CBW3; Q3U8V0; Q60747; Q91ZM5; Q923I9; Q99KH4 

Genbank Protein ID

 AF420251; AY033645; AK034476; AK152061; AK152184; AK151026; BC004657; U17698 

Genbank Nucleotide ID

 AAL16036.1; AAK59381.1; BAC28722.1; BAE30917.1; BAE31015.1; BAE30044.1; AAH04657.1; AAB00373.1 

Protein Name

 Abl interactor 1 

Protein Synonyms/Alias

 Abelson interactor 1; Abi-1; Ablphilin-1; Eps8 SH3 domain-binding protein; Eps8-binding protein; Spectrin SH3 domain-binding protein 1; e3B1 

Gene Name

 Abi1 

Gene Synonyms/Alias

 Ssh3bp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
154	DDVGHGVKHGNNQPA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. 

Sequence Annotation

 DOMAIN 45 107 t-SNARE coiled-coil homology.
 DOMAIN 419 478 SH3.
 REGION 18 79 Required for binding to WASF1.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 213 213 Phosphotyrosine; alternate.
 MOD_RES 213 213 Phosphotyrosine; by ABL1; alternate (By
 MOD_RES 216 216 Phosphoserine (By similarity).
 MOD_RES 222 222 Phosphoserine.
 MOD_RES 225 225 Phosphoserine (By similarity).
 MOD_RES 296 296 Phosphoserine (By similarity).
 MOD_RES 428 428 Phosphotyrosine.
 MOD_RES 480 480 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Cell junction; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome; SH3 domain; Synapse; Synaptosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 481 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
 GO:0005622; C:intracellular; ISA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0043005; C:neuron projection; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0030296; F:protein tyrosine kinase activator activity; IDA:MGI.
 GO:0006928; P:cellular component movement; IEA:Compara.
 GO:0072673; P:lamellipodium morphogenesis; IMP:MGI.
 GO:0035855; P:megakaryocyte development; IMP:MGI.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; ISA:MGI.
 GO:0001756; P:somitogenesis; IMP:MGI. 

Interpro

 IPR012849; Abl-interactor_HHR_dom.
 IPR000108; p67phox.
 IPR001452; SH3_domain.
 IPR000727; T_SNARE_dom. 

Pfam

 PF07815; Abi_HHR
 PF00018; SH3_1 

SMART

 SM00326; SH3 

PROSITE

 PS50002; SH3
 PS50192; T_SNARE 

PRINTS

 PR00499; P67PHOX.
 PR00452; SH3DOMAIN.