UniProt Accession

 PENK_HUMAN; P01210; B2RC23; Q6FHC6; Q6FHE6 

Genbank Protein ID

 V00509; J00123; J00122; AK314908; CR541808; CR541828; CH471068; BC032505 

Genbank Nucleotide ID

 CAA23767.1; AAB59409.1; AAB59409.1; BAG37420.1; CAG46607.1; CAG46627.1; EAW86785.1; AAH32505.1 

Protein Name

 Proenkephalin-A 

Protein Synonyms/Alias

 Synenkephalin; Met-enkephalin; Opioid growth factor; OGF; PENK(114-133); PENK(143-183); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(237-258); Met-enkephalin-Arg-Phe 

Gene Name

 PENK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
235	KRYGGFLKRFAEALP	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. 

Sequence Annotation

 DISULFID 26 48
 DISULFID 30 52
 DISULFID 33 65  

Keyword

 3D-structure; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Endorphin; Neuropeptide; Opioid peptide; Polymorphism; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 267 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005184; F:neuropeptide hormone activity; TAS:ProtInc.
 GO:0001662; P:behavioral fear response; IEA:Compara.
 GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
 GO:0019233; P:sensory perception of pain; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR006024; Opioid_neupept.
 IPR000703; Proenkphlin_A. 

Pfam

 PF01160; Opiods_neuropep 

SMART

  

PROSITE

 PS01252; OPIOIDS_PRECURSOR 

PRINTS

 PR01028; OPIOIDPRCRSR.
 PR01029; PENKAPRCRSR.