CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021183
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein FAM192A 
Protein Synonyms/Alias
 NEFA-interacting nuclear protein NIP30 
Gene Name
 FAM192A 
Gene Synonyms/Alias
 C16orf94; NIP30; CDA018; CDA10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13DGNLIIKKRFVSEAEubiquitination[1]
65LQEQKDRKQQEYEEQubiquitination[1]
134ENKKEVEKKLTVKPIacetylation[2]
139VEKKLTVKPIETKNKacetylation[2]
144TVKPIETKNKFSQAKacetylation[2]
151KNKFSQAKLLAGAVKubiquitination[3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 139 139 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 254 AA 
Protein Sequence
MDGGDDGNLI IKKRFVSEAE LDERRKRRQE EWEKVRKPED PEECPEEVYD PRSLYERLQE 60
QKDRKQQEYE EQFKFKNMVR GLDEDETNFL DEVSRQQELI EKQRREEELK ELKEYRNNLK 120
KVGISQENKK EVEKKLTVKP IETKNKFSQA KLLAGAVKHK SSESGNSVKR LKPDPEPDDK 180
NQEPSSCKSL GNTSLSGPSI HCPSAAVCIG ILPGLGAYSG SSDSESSSDS EGTINATGKI 240
VSSIFRTNTF LEAP 254 
Gene Ontology
 GO:0005634; C:nucleus; IDA:LIFEdb. 
Interpro
 IPR019331; Nefa_Nip30_N. 
Pfam
 PF10187; Nefa_Nip30_N 
SMART
  
PROSITE
  
PRINTS