UniProt Accession

 CBPA_ECOLI; P36659; P77250 

Genbank Protein ID

 D16500; U00096; AP009048 

Genbank Nucleotide ID

 BAA03950.1; AAC74085.1; BAA36142.1 

Protein Name

 Curved DNA-binding protein 

Protein Synonyms/Alias

  

Gene Name

 cbpA 

Gene Synonyms/Alias

 b1000; JW0985 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
13	YYAIMGVKPTDDLKT	acetylation	[1]
19	VKPTDDLKTIKTAYR	acetylation	[1, 2]
22	TDDLKTIKTAYRRLA	acetylation	[1, 2]
31	AYRRLARKYHPDVSK	acetylation	[1, 2]
38	KYHPDVSKEPDAEAR	acetylation	[1]
47	PDAEARFKEVAEAWE	acetylation	[1]
158	MIEQEIPKTLNVKIP	acetylation	[1]
163	IPKTLNVKIPAGVGN	acetylation	[1, 2]
234	KVTVPTLKESILLTI	acetylation	[1]
261	KGKGLVSKKQTGDLY	acetylation	[1]
262	GKGLVSKKQTGDLYA	acetylation	[1]
278	LKIVMPPKPDENTAA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM. 

Sequence Annotation

 DOMAIN 5 69 J.  

Keyword

 3D-structure; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 306 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:HAMAP.
 GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
 GO:0003681; F:bent DNA binding; IDA:EcoliWiki.
 GO:0006457; P:protein folding; IEA:InterPro. 

Interpro

 IPR023859; DNA-bd_curved-DNA.
 IPR002939; DnaJ_C.
 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS.
 IPR008971; HSP40/DnaJ_pept-bd. 

Pfam

 PF00226; DnaJ
 PF01556; DnaJ_C 

SMART

 SM00271; DnaJ 

PROSITE

 PS00636; DNAJ_1
 PS50076; DNAJ_2 

PRINTS

 PR00625; JDOMAIN.