CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029980
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myotubularin 
Protein Synonyms/Alias
  
Gene Name
 Mtm1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
252PLVGMSGKRNKDDEKubiquitination[1]
255GMSGKRNKDDEKYLDubiquitination[1]
259KRNKDDEKYLDVIREubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 572 AA 
Protein Sequence
MASASASKYN SHSLENESIK KVSQDGVSQD VSETVPRLPG ELLITEKEVI YICPFNGPIK 60
GRVYITNYRL YLRSLETDSA LILDVPLGVI SRIEKMGGAT SRGENSYGLD ITCKDLRNLR 120
FALKQEGHSR RDMFEILVKH AFPLAHNLPL FAFVNEEKFN VDGWTVYNPV EEYRRQGLPN 180
HHWRISFINK CYELCETYPA LLVVPYRTSD DDLRRIATFR SRNRLPVLSW IHPENKMVIM 240
RCSQPLVGMS GKRNKDDEKY LDVIRETNKQ TSKLMIYDAR PSVNAVANKA TGGGYESDDA 300
YQNSELSFLD IHNIHVMRES LKKVKDIVYP NIEESHWLSS LESTHWLEHI KLVLTGAIQV 360
ADQVSSGKSS VLVHCSDGWD RTAQLTSLAM LMLDSFYRTI EGFEILVQKE WISFGHKFAS 420
FPTAFEFNEG FLITVLDHLY SCRFGTFLFN CDSARERQKL TERTVSLWSL INSNKDKFKN 480
PFYTKEINRV LYPVASMRHL ELWVNYYIRW NPRVKQQQPN PVEQRYMELL ALRDDYIKRL 540
EELQLANSAK LADAPASTSS SSQMVPHVQT HF 572 
Gene Ontology
 GO:0031674; C:I band; IDA:MGI.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0048311; P:mitochondrion distribution; IMP:MGI.
 GO:0046716; P:muscle cell homeostasis; IMP:MGI.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR004182; GRAM.
 IPR010569; Myotub-related.
 IPR017906; Myotubularin_phosphatase_dom.
 IPR011993; PH_like_dom.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS. 
Pfam
 PF02893; GRAM
 PF06602; Myotub-related 
SMART
 SM00568; GRAM 
PROSITE
 PS51339; PPASE_MYOTUBULARIN
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2 
PRINTS