| Tag | Content |
|---|
| CPLM ID | CPLM-008375 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription factor 12 |
Protein Synonyms/Alias | TCF-12; DNA-binding protein HTF4; E-box-binding protein; Salivary-specific cAMP response element-binding protein alpha; SCBP-alpha; Transcription factor HTF-4 |
Gene Name | Tcf12 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 151 | AQLSSSGKPGTPYYS | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). |
Sequence Annotation | DOMAIN 602 655 bHLH.
REGION 119 140 Leucine-zipper.
REGION 657 680 Class A specific domain.
MOD_RES 67 67 Phosphoserine (By similarity).
MOD_RES 313 313 Phosphothreonine (By similarity).
MOD_RES 333 333 Phosphoserine (By similarity).
MOD_RES 582 582 Phosphothreonine (By similarity).
MOD_RES 584 584 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 707 AA |
Protein Sequence | MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG MDERGGTTSW 60
GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGTHEGLSPT PFMNSNLIGK TSERGSFSLY 120
SRDSGLSGCQ SSLLRQDLGL GSPAQLSSSG KPGTPYYSFS ATSSRRRPLH DSVALDPLQA 180
KKVRKVPPGL PSSVYAPSPN SDDFNRESPS YPSPKPPTSM FASTFFMQDG THSSSDLWSS 240
SNGMSQPGFG GILGTSTSHM SQSSSYGSLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG 300
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD HTSSSFPSNP 360
STPVGSPSPL TAGTSQWPRA GGQAPSSPSY ENSLHSLKNR VEQQLHEHLQ DAMSFLKDVC 420
EQSRMEDRLD RLDDAIHVLR NHAVGPSTSL PTSHSDIHSL LGPSHNAPIG NLNSNYGGSS 480
LVTNSRSASM VGTHREDSVS LNGNHSVLSS TVAASNTELN HKTPESFRGG VQNQSGSVVP 540
TEIKTENKEK DENLHEPPSS DDMKSDDESS QKDIKVSSRG RTSSTNEDED LNPEQKIERE 600
KERRMANNAR ERLRVRDINE AFKELGRMCQ LHLKSEKPQT KLLILHQAVA VILSLEQQVR 660
ERNLNPKAAC LKRREEEKVS AASAEPPTTL PGTHPGLSET TNPMGHL 707 |
Gene Ontology | GO:0005634; C:nucleus; IDA:MGI. GO:0035497; F:cAMP response element binding; IDA:RGD. GO:0070888; F:E-box binding; ISS:UniProtKB. GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB. GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |