| Tag | Content |
|---|
| CPLM ID | CPLM-024457 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DENN domain-containing protein 4C |
Protein Synonyms/Alias | |
Gene Name | Dennd4c |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 286 | SQERLTEKQLTQLGL | ubiquitination | [1] | | 590 | ITEAPSNKATAADSL | ubiquitination | [1] | | 716 | YFPRLDLKLFDSPQK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. |
Sequence Annotation | DOMAIN 40 199 MABP.
DOMAIN 202 275 uDENN.
DOMAIN 307 491 DENN.
DOMAIN 557 631 dDENN.
REPEAT 818 852 PPR.
MOD_RES 740 740 Phosphoserine (By similarity).
MOD_RES 971 971 Phosphoserine (By similarity).
MOD_RES 987 987 Phosphoserine (By similarity).
MOD_RES 1000 1000 Phosphoserine (By similarity).
MOD_RES 1043 1043 Phosphoserine.
MOD_RES 1096 1096 Phosphoserine.
MOD_RES 1123 1123 Phosphoserine (By similarity).
MOD_RES 1181 1181 Phosphoserine (By similarity).
MOD_RES 1221 1221 Phosphoserine (By similarity).
MOD_RES 1240 1240 Phosphoserine (By similarity).
MOD_RES 1274 1274 Phosphoserine (By similarity).
MOD_RES 1321 1321 Phosphoserine.
MOD_RES 1342 1342 Phosphoserine (By similarity).
MOD_RES 1620 1620 Phosphoserine (By similarity).
MOD_RES 1624 1624 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1906 AA |
Protein Sequence | MIEDKGPRVT DYFVVAGLTD TSTLLDQEIN RTDTNSIGPK APITDIAVII KSAGETVPEG 60
YTCVEATPSA LQANLNYGSL KSPELFLCYR RGRDKPPLTD IGVLYEGKER LMPGCEVIQA 120
TPYGRCANVN NSSTTSQRIF ITYRRAPPVR SQNSLAVTDI CVIITSKGET PPHTFCKVDK 180
NLNCGMWGSN VFLCYKKSVP ASNAIAYKAG LIFRYPEEDY ESFPLSPSVP LFCLPMGATI 240
ECWDPQIKYP LPVFSTFVLT GSSAEKVYGA AIQFYEPYSQ ERLTEKQLTQ LGLLTLVEKR 300
VVSKPINSNK CICLLSHWPF FEAFKNFLMF IYKVSVSGPH PLPIEKHISH FMQNIPFPSP 360
QRPRILIQLS VHDAFILSQP VSTPLPLSGA NFSSLLMNLG PENCATLLLL VLLESKILLH 420
SLRPAVLTGV AEAVVAMIFP FQWQCPYIPL CPLSLAGVLS APLPFIVGVD SRYFDLHDPP 480
QDVVCIDLDT NTLYVADERK NINWKQLPKR PCKSLLGTLR RLYQQLCSVH RKPQESSAIE 540
MTPIEADYSW QKKMTQLEME IQETFLRFMA SILKGYRSYL RPITEAPSNK ATAADSLFDR 600
QGFLKSRDRA YTKFYTLLSK TQIFIRFIEE CSFVSDKDTG LAFFDDCIEK LFPDKGVERT 660
EKVDLDSAED TRLIELDDSQ RSEHTVFIMP PEPPPDDGNN LSPQYSYTYF PRLDLKLFDS 720
PQKLKLCFNR HPPGSSITNS PALMAKRTKQ EIKTAHKLAK RCYTNPPQWA KYLFSHCYSL 780
WFICLPAYVR VSHPKVRALQ QAHDVLVKMR KTDVDPLDEV CYRVVMQLCG LWVNPVLAVR 840
VLFEMKTARI KPNAITYGYY NKVVLESPWP SSTRSGIFLW TKVRNVVHGL AQFRQPLKKT 900
GQKSQVFSIS GGQSDQGYGS KDELVKEGAD GHAPEEHTPP ELTTTELHIE EECDISAIVS 960
KHLQPTPEPQ SPTEPPAWGS SIVKVPSGLF DTNNRTSTGS TSTVLFSTQA PVEDAVFSEV 1020
TNFKKNGDRG EKKQKHFPER SCSFSSESRA GMLLKKSSLD LNSSEMAIMM GADAKILTAA 1080
LTCPKTSPPH VTRTHSFENV NCHLADSRTR MSEGTRDSEH RSSPVLEMLE ESQELLEPVV 1140
GDNVAETAAE MTCNSLQSNS HSDQSRDTQA GAQDPVNKRS SSYATRKAIE REDVETGLDP 1200
LSLLATECVE KTSDSEDKLF SPVISRNLAD EIESYMNLKS PLGSKSCSME LHGEGNQEPG 1260
SPAVFAHPLE RSSSLPSDRG PPARDSTETE KSSPAVSSSK TLTGRFKPQS PYRAYKDRST 1320
SLSALVRSSP NSSLGSVVNS LSGLKLDNIL SGPKIDVLKS SMKQAATVAS KMWVAVASAY 1380
SYSDDEEETN KDYSFPAGLE DHHIVGETLS PNTSVSGLVP SELTQSNTSL GSSSSSGDVG 1440
KLQCPAGEVP FSRNIKGQDF EKSDHGSSQN TSMSSIYQNC AMEVLMSSCS QCRACGALVY 1500
DEEIMAGWTA DDSNLNTTCP FCKSNFLPLL NVEFKDLRGS ASFFLKPSTS GDSLQSGSIP 1560
SASEPSEHKP TSSSAEPDLI SFMDFSKHSE TITEEASYTV ESSDEIKKTN GDVQSVKMSS 1620
VPNSLSKRNV SLTRSHSVGG PLQNIDFSQR PFHGVSTVSL PSSLQEDVDH LGKRPSPPPV 1680
SVPYLSPLVL RKELESLLEN EGDQVIHTSS FINQHPIIFW NLVWYFRRLD LPSNLPGLIL 1740
TSEHCNGGVQ LPLSSLSQDS KLVYIQLLWD NINLHQEPGE PLYVSWRNLN SEKKPSLLSE 1800
QQQAASALVE TIRQSIQQND VLKPINLLSQ QMKPGTKRQR SLYREILFLS LVSLGRENID 1860
IEAFDNEYGL AYRSLPSESL ERLQRIDAPP SISVEWCRKC FGAPLI 1906 |
Gene Ontology | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0005829; C:cytosol; IDA:UniProtKB. GO:0032593; C:insulin-responsive compartment; IDA:UniProtKB. GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0030904; C:retromer complex; IDA:MGI. GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB. GO:0032869; P:cellular response to insulin stimulus; IMP:UniProtKB. GO:0072659; P:protein localization to plasma membrane; IMP:UniProtKB. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |