UniProt Accession

 RAB21_MOUSE; P35282; Q7TPN7 

Genbank Protein ID

 BC055042; M79302 

Genbank Nucleotide ID

 AAH55042.1; AAK14826.1 

Protein Name

 Ras-related protein Rab-21 

Protein Synonyms/Alias

 Rab-12 

Gene Name

 Rab21 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
41	VLRYCENKFNDKHIT	acetylation	[1]
136	GNKIDLEKERHVSIQ	ubiquitination	[2]
155	YAESVGAKHYHTSAK	ubiquitination	[2]
165	HTSAKQNKGIEELFL	ubiquitination	[2]
176	ELFLDLCKRMIETAQ	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. 

Sequence Annotation

 NP_BIND 24 32 GTP (By similarity).
 NP_BIND 72 76 GTP (By similarity).
 NP_BIND 130 133 GTP (By similarity).
 NP_BIND 160 162 GTP (By similarity).
 MOTIF 46 54 Effector region (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 219 219 Cysteine methyl ester (Potential).
 LIPID 218 218 S-geranylgeranyl cysteine (By
 LIPID 219 219 S-geranylgeranyl cysteine (By  

Keyword

 Acetylation; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Endoplasmic reticulum; Endosome; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.