CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011120
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase VHS1 
Protein Synonyms/Alias
 Viable in a HAL3 SIT4 background protein 1 
Gene Name
 VHS1 
Gene Synonyms/Alias
 YDR247W; YD8419.14 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
51VQSYGVSKEADMGNDubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Probable serine/threonine protein kinase involved in the G1-S transition. 
Sequence Annotation
 DOMAIN 12 337 Protein kinase.
 NP_BIND 18 26 ATP (By similarity).
 ACT_SITE 185 185 Proton acceptor (By similarity).
 BINDING 41 41 ATP (By similarity).  
Keyword
 ATP-binding; Cell cycle; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 461 AA 
Protein Sequence
MMMFHNCRIN NYLITSQIGE GAYGLVYRAL DIRTDRQYAI KAVVQSYGVS KEADMGNDKI 60
HKNSVKLQKK LAKLFKESKN VVRVPSIDLE SIENMSEEDF KKLPHYKEIS LHLRVHHHKN 120
IVTIHEVLQS AVCTFIVMDY YPTDLFTSIV DNRHFVTNGL LVKKVFLQIC SALNYCHEHG 180
IYHCDIKPEN LLLDTEDNVF LCDFGLSTTS TYIKPNVCIG SSYYMPPERI SFDGRVSSSK 240
SGGHKLGKVC PSCNGDLWSL GIILINLTCI RNPWLKADKT EDNTYYYFTK DPNILKQILP 300
LSDDFYSLLS KILQVNPKNR MSLQELMKEV SSITSFTNEG PLSKVPPLSK SVYEKFVSPV 360
DNTNENLSPK SYVYMHDSKA AKNLSYTSSS EEEDGIKEGI DDDNGSRSGS FGTLDTDTGL 420
HSSFTSTSCE SDNECSKISN KFSLFEKKFN ELRMSSSSLT N 461 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:SGD.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IGI:SGD. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS