UniProt Accession

 RUXE_YEAST; Q12330; D6W2L6 

Genbank Protein ID

 X92449; U55020; Z75067; AY558029; BK006948 

Genbank Nucleotide ID

 CAA63198.1; AAC49645.1; CAA99365.1; AAS56355.1; DAA10932.1 

Protein Name

 Small nuclear ribonucleoprotein E 

Protein Synonyms/Alias

 snRNP-E; Sm protein E; Sm-E; SmE 

Gene Name

 SME1 

Gene Synonyms/Alias

 YOR159C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
79	EKGTPLGKILLKGDN	ubiquitination	[1]
83	PLGKILLKGDNITLI	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 94 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005685; C:U1 snRNP; IDA:SGD.
 GO:0071004; C:U2-type prespliceosome; IDA:SGD.
 GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:SGD.
 GO:0005682; C:U5 snRNP; IDA:SGD.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000398; P:mRNA splicing, via spliceosome; IPI:SGD. 

Interpro

 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc.
 IPR027078; snRNP-E. 

Pfam

 PF01423; LSM 

SMART

 SM00651; Sm 

PROSITE

  

PRINTS