UniProt Accession

 GRAP_HUMAN; Q13588 

Genbank Protein ID

 U52518; BT019981; CR541941; CR541966; AC003957; AC007952; BC035856; BC063035 

Genbank Nucleotide ID

 AAC50541.1; AAV38784.1; CAG46739.1; CAG46764.1; AAH35856.1; AAH63035.1 

Protein Name

 GRB2-related adapter protein 

Protein Synonyms/Alias

  

Gene Name

 GRAP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	SDELAFNKGDTLKIL	ubiquitination	[1]
38	EDDQNWYKAELRGVE	ubiquitination	[1]
56	PKNYIRVKPHPWYSG	ubiquitination	[1]
76	LAEEILMKRNHLGAF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. 

Sequence Annotation

 DOMAIN 1 58 SH3 1.
 DOMAIN 60 154 SH2.
 DOMAIN 158 217 SH3 2.  

Keyword

 Complete proteome; Reference proteome; Repeat; SH2 domain; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0007265; P:Ras protein signal transduction; TAS:ProtInc. 

Interpro

 IPR000108; p67phox.
 IPR000980; SH2.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF00017; SH2
 PF00018; SH3_1
 PF07653; SH3_2 

SMART

 SM00252; SH2
 SM00326; SH3 

PROSITE

 PS50001; SH2
 PS50002; SH3 

PRINTS

 PR00499; P67PHOX.
 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.